Loop Analysis of the Anal Sphincter Complex in Fecal Incontinent Patients using Functional Luminal Imaging Probe.

Loop Analysis of the Anal Sphincter Complex in Fecal Incontinent Patients using Functional Luminal Imaging Probe. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 18;: Authors: Zifan A, Mittal RK, Kunkel DC, Swartz J, Barr G, Tuttle LJ Abstract BACKGROUND AND AIMS: Cardiac loops have been used extensively to study myocardial function. With changes in cardiac pump function, loops are shifted to the right or left. Functional luminal imaging probe (FLIP) recordings allow for loop analysis of anal sphincter and puborectalis (PRM) function. The goal was to characterize anal sphincter area-pressure/tension loop changes in fecal incontinence (FI) patients. METHODS: 14 healthy subjects and 14 patients with FI were studied. Custom-designed FLIP was placed in the vagina and then in the anal canal, and deflated in 20ml steps, from 90-30ml. At each volume, subjects performed maximal voluntary squeezes. Area-pressure (AP) and area-tension (AT) loops were generated for each squeeze cycle. 3D-US imaging of the anal sphincter and PRM were obtained to determine the relationship between anal sphincter muscle damage and loop movements. RESULTS: With an increase in bag volume, AP-loops and AT-loops shifted to the right and upwards in normal subjects (both anal and vaginal). The shift to the right was greater, and upwards movement less in FI patients. The difference in the location of AP-loops and AT-loops was statistically significant at volumes of 50ml to 90ml (...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

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Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Authors: von Kodolitsch Y, Demolder A, Girdauskas E, Kaemmerer H, Kornhuber K, Muino Mosquera L, Morris S, Neptune E, Pyeritz R, Rand-Hendriksen S, Rahman A, Riise N, Robert L, Staufenbiel I, Szöcs K, Vanem TT, Linke SJ, Vogler M, Yetman A, De Backer J Abstract Introduction: The revised Ghent nosology presents classical features of Marfan syndrome. However, behind its familiar face, Marfan syndrome hides less well-known features.Areas covered: The German Marfan Organization listed unusual symptoms and clinical experts reviewed the literature on clinical features of Marfan syndrome not listed in the Ghent nosol...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
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Source: Abdominal Imaging - Category: Radiology Source Type: research
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Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
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Source: International Urogynecology Journal - Category: OBGYN Source Type: research
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Source: International Urogynecology Journal - Category: OBGYN Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
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