Loop Analysis of the Anal Sphincter Complex in Fecal Incontinent Patients using Functional Luminal Imaging Probe.

Loop Analysis of the Anal Sphincter Complex in Fecal Incontinent Patients using Functional Luminal Imaging Probe. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 18;: Authors: Zifan A, Mittal RK, Kunkel DC, Swartz J, Barr G, Tuttle LJ Abstract BACKGROUND AND AIMS: Cardiac loops have been used extensively to study myocardial function. With changes in cardiac pump function, loops are shifted to the right or left. Functional luminal imaging probe (FLIP) recordings allow for loop analysis of anal sphincter and puborectalis (PRM) function. The goal was to characterize anal sphincter area-pressure/tension loop changes in fecal incontinence (FI) patients. METHODS: 14 healthy subjects and 14 patients with FI were studied. Custom-designed FLIP was placed in the vagina and then in the anal canal, and deflated in 20ml steps, from 90-30ml. At each volume, subjects performed maximal voluntary squeezes. Area-pressure (AP) and area-tension (AT) loops were generated for each squeeze cycle. 3D-US imaging of the anal sphincter and PRM were obtained to determine the relationship between anal sphincter muscle damage and loop movements. RESULTS: With an increase in bag volume, AP-loops and AT-loops shifted to the right and upwards in normal subjects (both anal and vaginal). The shift to the right was greater, and upwards movement less in FI patients. The difference in the location of AP-loops and AT-loops was statistically significant at volumes of 50ml to 90ml (...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

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Kathy Siggins and Lynda Everman are thrilled to share the welcome news that the US Postal Service has reinstated sales of the Alzheimer’s Disease Research Semipostal Stamp effective October 5, 2020. It is now available for purchase at most post offices and online at https://store.usps.com/store/product/buy-stamps/alzheimers-S_564204, and by phone at 1-800 STAMP-24. Before it was withdrawn in November 2019, over 8.2 million stamps were sold during its two-year run raising $1,061,777 for NIH-supported research to advance better treatments, prevention, and one day, a cure of Alzheimer’s and related dementias. The ...
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In this study, we have evaluated the efficiency of fractional carbon dioxide laser in the treatment of vaginal laxity and urinary incontinence. Thirty patients with vaginal laxity, sexual dysfunction and urinary incontinence complaints were treated with fractional carbon dioxide laser. Results were evaluated with patient questionnaires relating to comfort during the procedure and general satisfaction following the procedure. In the survey regarding comfort during the procedure, 90% (n:27) of the patients reported that they were comfortable during the procedure. The survey on the level of general satisfaction six months fol...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
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Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
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