The down regulation of PTP1B expression and attenuation of disturbed glucose and lipid metabolism using Borassus flabellifer (L) fruit methanol extract in High Fat Diet and Streptozotocin induced diabetic rats

Publication date: Available online 18 November 2019Source: Saudi Journal of Biological SciencesAuthor(s): V. Duraipandiyan, R. Balamurugan, Naif Abdullah Al-Dhabi, T. William Raja, P. Ganesan, B. Ahilan, M. Valan Arasu, S. Ignacimuthu, Galal Ali EsmailAbstractBorassus flabellifer L. is a tall palm traditionally used for its stimulating, diuretic and anti-inflammatory activities; it is rich in fibers and various pharmacologically important secondary metabolites. The present study was undertaken to evaluate the antidiabetic effects of Borassus flabellifer fruit methanol extract (BF-M) on diabetic rats induced with High Fat Diet (HFD) / streptozotocin (STZ). When BF-M (100 or 200 mg/kg) was administered for 21 days orally it led to a sharp decline in triglycerides, total cholesterol, free unsaturated fat, glucose-6-phosphate, fasting blood glucose and fructose 1,6 bisphosphatase in contrast to diabetic control. BF-M also downregulated Protein Tyrosine Phosphatase 1B. In vitro study showed the IC50 value to be 23.98 μg/mL. BF-M significantly increased serum insulin, glycogen content, and body weight. Western blot analysis exhibited significant inhibition of PTP1B in pancreatic tissue which was confirmed by histology and immunohistological studies. GC-MS analysis showed the presence of major compounds such as 5-hydroxymethylfurfural (47.56%), Guanosine (21.01%) and n-hecxadeconoic acid (25.14 %) in BF-M. In short, BF-M exerted antidiabetic property by down regulating PTP1B expr...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research

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CONCLUSIONS: The presence of one or more prognostic factors as well as the various risk prediction models can guide selection of ACS patient subgroups for which a prophylactic CEA should or should not be offered. Decisions to offer prophylactic CEA should weigh in factors like surgeon's experience and hospital expertise/volume. Asymptomatic patients not expected to live long enough to benefit from the procedure should not be considered for CEA, but should be offered best medical treatment. PMID: 31814375 [PubMed - as supplied by publisher]
Source: International Angiology - Category: Cardiology Tags: Int Angiol Source Type: research
ConclusionsComputational measures reflecting individual PVS size, length and width were more strongly associated with WMH, stroke and hypertension than computational count or visual PVS score. Multidimensional computational PVS metrics may increase sensitivity to detect associations of PVS with risk exposures, brain lesions and neurological disease, provide greater anatomic detail and accelerate sunderstanding of disorders of brain fluid and waste clearance.Graphical abstract
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionCompared with placebo or any other comparator, PCSK9-mAb treatment was not associated with the adverse event of diabetes. However, evolocumab and alirocumab show high risk of incident diabetes when there is no interference from unbalanced use of statins. The imbalance in background lipid modifying therapy or different comparators used in the control arms of the studies might have masked the effect of PCSK9-mAb therapy on diabetes.
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
ConclusionMCS has an anti-diabetic effect, which may be related to its improving the lipid metabolism disorder, reducing oxidative stress level and regulating insulin signaling pathway.
Source: Electronic Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 9 December 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Francesca Saitta, Marco Signorelli, Dimitrios FessasAbstractA fifteen-components model membrane that reflected the 80% of phospholipids present in Insulin Secretory Granules was obtained and thermodynamic exploitation was performed, through micro-DSC, in order to assess the synergic contributions to the stability of a mixed complex system very close to real membranes. Simpler systems were also stepwise investigated, to complete a previous preliminary study and to highlight a hierarchy of interactions that can be now s...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
MHRA aware of issue and advises patients to continue to taking their diabetes medicine Related items fromOnMedica People on statins at greater risk of skin infections and diabetes Raised risk of MI and mortality when starting sulfonylurea Use of DPP-4 inhibitors associated with increased risk of IBD Vitamin D does not reduce kidney damage in type 2 diabetes Use pioglitazone only in selected patients, says EMA guidance
Source: OnMedica Latest News - Category: UK Health Source Type: news
Publication date: Available online 9 December 2019Source: Journal of Functional FoodsAuthor(s): Milkica Grabež, Ranko Škrbić, Miloš P. Stojiljković, Vesna Rudić-Grujić, Marija Paunović, Aleksandra Arsić, Snježana Petrović, Vesna Vučić, Bosa Mirjanić-Azarić, Katarina Šavikin, Nebojša Menković, Teodora Janković, Nađa VasiljevićAbstractPomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Limiting food and drink consumption to a 10-hour daily window could improve body composition, blood pressure and cholesterol levels in adults with metabolic syndrome, according to research presented at the World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
This study aimed to determine, in women with gestational diabetes (GDM), the changes in insulin sensitivity (Matsuda Insulin Sensitivity Index; ISOGTT), insulin response and disposition index (DI) from late pregnancy (34 –37 weeks gestation, T1), to early postpartum (1–5 days, T2) and late postpartum (6–12 weeks, T3). A secondary aim was to correlate the longitudinal changes in maternal lipids, adipokines, cytokines and weight in relation to the changes in ISOGTT, insulin response and DI.MethodsISOGTT, insulin response and DI were calculated at the three time points (T1, T2 and T3) using th...
Source: Diabetologia - Category: Endocrinology Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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