Plasma D-dimer as a predictor of intraluminal thrombus burden and progression of abdominal aortic aneurysm

This study investigated the interrelation between plasma D-dimer level, ILT volume, AAA size and progression.Main methodsThis was a retrospective observational study that involved 181 patients with infra-renal AAA. They were divided into small and large AAA groups according to AAA diameter. 24 of them had repeated abdominal computed tomography angiography (CTA) scan and were divided into slow-growing and fast-growing AAA groups according to the median value of AAA growth rate. Baseline and follow-up plasma D-dimer level, maximum diameter of AAA, total infra-renal aortic volume and ILT volume were analyzed.Key findingsPlasma D-dimer level was positively correlated with ILT volume (R = 0.382, P 
Source: Life Sciences - Category: Biology Source Type: research

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Authors: Simka M, Hobot J, Skuła M PMID: 31782282 [PubMed - as supplied by publisher]
Source: International Angiology - Category: Cardiology Tags: Int Angiol Source Type: research
Introduction: Macrophages in the aneurysmal wall play an important role in the pathogenesis of abdominal aortic aneurysms (AAAs). superparamagnetic iron oxide (SPIO) is a macrophage-specific contrast agent that result in negative enhancement on T2*-weighted imaging. SPIO-enhanced MRI targeting the mural thrombus of AAAs was reported, and the signal level of thrombi showed a decrease after SPIO injection. However, the macrophages in the media and adventitia of AAA wall has not been investigated in detail.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Introduction - Shaggy aorta is related to early adverse events following endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm, specially peripheral and visceral embolization from the aorta.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Introduction - The intra-luminal thrombus (ILT) in abdominal aortic aneurysms (AAA) is suggested to weaken the aortic wall and contribute to aneurysm growth and eventually rupture (1 –4). Thus, investigation of ILT has the potential to improve rupture risk prediction which today is predominantly based on diameter alone. Until recently, the ILT volume could only be determined by means of three-dimensional computed tomography angiography (3D-CTA) and ultrasound has not had a pla ce in this context, although attractive due to its noninvasive nature.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Introduction - Most clinically relevant abdominal aortic aneurysms (AAA) contain an intraluminal thrombus (ILT) 1. The ILT entraps neutrophils, which secrete elastase with fibrinolytic activity, the process of which yields specific ‘neutrophil elastase-derived cross-linked fibrin degradation products’ (E-XDP) 2. Our hypothesis was that circulating E-XDP could reveal the presence, size and mechanical stress of AAAs and its ILTs.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Thrombosis of an endovascular aortic repair (EVAR) is a devastating complication of a common surgical procedure that can lead to serious morbidity and mortality if not promptly recognized. This is the first case report of an EVAR graft thrombosis in the emergency medicine literature.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Intraluminal thrombus (ILT) is almost ubiquitously associated with abdominal aortic aneurysm (AAA), but its role in the pathophysiologic mechanism of AAA remains unclear after more than two decades of speculation. This systematic review and meta-analysis reached the not surprising conclusion that larger AAAs have more ILT than small AAAs. It, however, still stops short of concluding whether ILT is a contributing or protective factor for aneurysm rupture.1
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Invited commentary Source Type: research
Abstract Abdominal aortic aneurysms (AAA) are localized, commonly occurring aortic dilations. Following rupture only immediate treatment can prevent morbidity and mortality. AAA maximal diameter and growth are the current metrics to evaluate the associated risk and plan intervention. Although these criteria alone lack patient specificity, predicting their evolution would improve clinical decision. If the disease is known to be associated with altered morphology and blood flow, intraluminal thrombus deposit and clinical symptoms, the growth mechanisms are yet to be fully understood. In this retrospective longitudin...
Source: Annals of Biomedical Engineering - Category: Biomedical Engineering Authors: Tags: Ann Biomed Eng Source Type: research
Conclusions: High EI of ILT may predict the occurrence of type II endoleaks after EVAR of AAA. PMID: 31621439 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Chronic thrombosis of an abdominal aortic aneurysm (AAA) is a rare entity and the ideal management is debatable.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research
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