Fluctuative profiling of microRNAs performance in carcinogenesis and tumorigenesis; an overview of cancer therapy

Publication date: Available online 18 November 2019Source: Life SciencesAuthor(s): Kosar Babaei, Shima Shams, Arman Keymoradzadeh, Sogand Vahidi, Parisa Hamami, Roya Khaksar, Seyedeh Elham Norollahi, Ali Akbar SamadaniAbstractImportance of dysregulation and expression of microRNAs (miRNAs) has been confiemed in many disorders comprising cancer. In this way, different approaches to induce reprogramming from one cell type to another in oerder to control the cell normal mechanisem, comprising microRNAs, combinatorial small molecules, exosome-mediated reprogramming, embryonic microenvironment and also lineage-specific transcription agents, are involved in cell situation. Meaningly, besides the above factors, microRNAs are so special and have an impressive role in cell reprogramming. One of the main applications of cancer cell reprogramming is it's ability in therapeutic approach. Many insights in reprogramming mechanism have been recommended, and determining improvment has been aknolwged to develop reprogramming efficiency and possibility, permiting it to appear as practical therapy against all cancers. Conspiciously, the recent studies on the fluctuations and performance of microRNAs,small endogenous non-coding RNAs, as notable factors in carcinogenesis and tumorigenesis, therapy resistance and metastasis and as new non-invasive cancer biomarkers has a remarkable attention. This is due to their unique dysregulated signatures throughout tumor progression. Recognising miRNAs signa...
Source: Life Sciences - Category: Biology Source Type: research