Swimming impacts on pancreatic inflammatory cytokines, miR-146a and NF- кB expression levels in type-2 diabetic rats.

CONCLUSION: Our results indicated a significant increase in expression levels of miR-146, NF-κB and inflammatory cytokines (IL-6, TNF-α, and IL-1β) while a significant decrease in pancreatic expression levels of TRAF6 and IRAK1 in diabetic group as compared to the control group. In contrast, swimming exercise resulted in a significant decrease in expression levels of miR-146a, NF-кB and inflammatory cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic group compared to the diabetic group. PMID: 31733638 [PubMed - as supplied by publisher]
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Tags: Curr Diabetes Rev Source Type: research

Related Links:

Researchers find that TV watching is the lifestyle habit most strongly associated with obesity in children Related items fromOnMedica GPs should lead on weight management advice to children UK children have already eaten 18 years ’ worth of sugar by 10th birthday Children order fast food from schools, report shows Put children ’s health, not private profits, at heart of policy Type 2 diabetes in 10 times more young people than realised
Source: OnMedica Latest News - Category: UK Health Source Type: news
For every one point lower BMI, people are at 1.37-fold lower risks for developing type 2 diabetes - even if they are not overweight or obese, new Stanford University research suggests.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A study found that a 1 kg/m squared reduction in BMI in non-overweight individuals reduced reduced their risk for developing type II diabetes by as much as 37 percent.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
by Michael Wainberg, Anubha Mahajan, Anshul Kundaje, Mark I. McCarthy, Erik Ingelsson, Nasa Sinnott-Armstrong, Manuel A. Rivas BackgroundLifestyle interventions to reduce body mass index (BMI) are critical public health strategies for type 2 diabetes prevention. While weight loss interventions have shown demonstrable benefit for high-risk and prediabetic individuals, we aimed to determine whether the same benefits apply to those at lower risk. Methods and findingsWe performed a multi-stratum Mendelian randomization study of the effect size of BMI on diabetes odds in 287,394 unrelated individuals of self-reported white Brit...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
ConclusionsPost-prandial plasma metabolomics profiles suggest that a 2-m-long BLP RYGB does not have a negative impact on acute metabolite absorption. RYGB BPL length seems to influence post-prandial acetate levels, which could contribute to the additional positive metabolic outcomes.
Source: Obesity Surgery - Category: Surgery Source Type: research
Gestational diabetes mellitus (GDM) has serious effects on both mother and child. Like Type 2 Diabetes Mellitus, it is increasing in prevalence world-wide. In addition to obesity, sleep duration has been named...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
AbstractCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T in the vascular system. Firstly, the mechanisms involved in the T vasodilator effect will be presented. Then, it will be discussed the association of T with the main risks for CVD, namely metabolic syndrome, ...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
This study found that increased levels of HMW oligomeric complex of CTRP3 were associated with higher circulating triglycerides. AbstractC1q/TNF ‐related protein 3 (CTRP3) is a relatively novel adipose tissue‐derived cytokine (adipokine) which has been linked to improved glucose regulation and insulin sensitivity. However, the relationship between circulating CTRP3 levels and diabetes is controversial. CTRP3 can circulate in different ol igomeric complexes: trimeric, hexameric, and high molecular weight (HMW) oligomeric complexes. However, the concentration of the different oligomeric complexes in human disease states ...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractAimThe aim of this study was to find independent perioperative factors predicting unsuccessful weight loss following one anastomosis gastric bypass-mini gastric bypass (OAGB-MGB), a recently developed technique of bariatric surgery.MethodsUsing regression analysis, this prospective cohort study assessed the role of demographic and socioeconomic factors, clinical features, body composition, length of biliopancreatic limb (LBL), nutritional habits, comorbidities, and early post-operative weight reduction values, in predicting 1-year weight loss after OAGB-MGB. All patients at the center who underwent laparoscopic OAG...
Source: Obesity Surgery - Category: Surgery Source Type: research
More News: Diabetes | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Endocrinology | High Fat | Insulin | Nutrition | Obesity | Pancreas | Sports Medicine | Study