The synthesis of an antifungal 1,2,4-triazole drug and the establishment of a drug delivery system based on zeolitic imidazolate frameworks

New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ04432A, PaperShulin Jiao, YaoJia Li, Zhiguo Gao, Ruicheng Chen, Yan Wang, Zhihong Zou Schematic representation of a drug delivery system based on ZIF-8 for the therapy of invasive Candida albicans infections. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research

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Abstract Condensation of rhodanine (1) with pyrazol-3(2H)-one derivatives (2a-f) gave 5-substituted-2-thioxo-1,3-thiazolidin-4-one derivatives (3a-f). Reaction of compound (1) with 2-arylmethylidene-malononitrile (4a-d) yielded the unexpected derivatives (5a-d). The latter compounds were subjected to cyclization reactions with malononitrile under different basic conditions, hydroxylamine hydrochloride and/or thiourea to furnish the fused thiazole derivatives (6a-d) and (8-10a-d). Coupling of (1) with diazotized aromatic amines (11a-c) in pyridine afforded the arylhydrazones (12a-c). Fusion of latter compounds with...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
In this study, uncoated and cationic CLZ-ALA-loaded SLN were prepared and compared. Suspensions with a narrow size distribution of particles of mean size below 150 nm were obtained, having slight negative or highly positive zeta potential values, due to the presence of the cationic lipid, which also increased nanoparticles stability, as confirmed by Turbiscan® results. Calorimetric studies confirmed the rationale of separately delivering the two drugs in a dual-delivery system. Furthermore, they confirmed the formation of SLN, without significant variation in presence of the cationic lipid. In vitro release stud...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 4 December 2019Source: The Journal of Prosthetic DentistryAuthor(s): Ji Suk Shim, Jong-Eun Kim, Sang Hoon Jeong, Yeon Jo Choi, Jae Jun RyuAbstractStatement of problemPrinting orientation is an important decision in the initial steps of additive manufacturing, affecting printing accuracy and the mechanical properties of printed products. In addition, printing orientation determines the building direction of layers and the layer-by-layer configuration forming the surface geometry.PurposeThe purpose of this in vitro study was to evaluate the effect of printing orientation on the printin...
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Staphylococcus aureus is responsible for a high number of relapsing infections, which are often mediated by the protective nature of biofilms. Polymicrobial biofilms appear to be more tolerant to antibiotic treatment, however, the underlying mechanisms for this remain unclear. Polymicrobial biofilm and planktonic cultures formed by S. aureus and Candida albicans are 10- to 100-fold more tolerant to oxacillin, vancomycin, ciprofloxacin, delafloxacin, and rifampicin compared to monocultures of S. aureus. The possibility of C. albicans matrix components physically blocking antibiotic molecules from reaching S. aureus was rule...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of gluten and characterized by reversible small-bowel mucosal atrophy in genetically predisposed subjects. Although the prevalence of CD has increased, many aspects of this pathology are still unrecognized. Candida albicans, a commensal of the human gastrointestinal tract, has been linked to CD for a long time based, among others, upon the observation of similarity between the fungal wall component, hyphal wall protein 1, and CD-related gliadin T-cell epitopes. We have recently demonstrated that Candida may switch from commensal to pathogen conti...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 3 December 2019Source: LWTAuthor(s): Jin-Young Han, Won-Jae Song, Joo Hyun Kang, Sea C. Min, Sangheum Eom, Eun Jeong Hong, Seungmin Ryu, Seongbong Kim, Sangwoo Cho, Dong-Hyun KangAbstractWe evaluated the effect of plasma-activated water (PAW) on the populations of foodborne pathogens and food-spoilage microorganisms on Korean rice cake. PAW was produced by treating distilled water with two atmospheric dielectric-barrier discharges (51.7 W, 14.4 kHz, air discharge) for 20 min. The inactivation effect of PAW on indigenous microorganism and inoculated Escherichia coli O157:H7, Salmonel...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
A total of 141 people have been infected with the drug-resistant Candida auris and 22 other patients probably have it, the state's department of health confirmed today.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 2 December 2019Source: Saudi Journal of Biological SciencesAuthor(s): Mohamed A. Dkhil, Rafat Zreiq, Taghreed A. Hafiz, Murad A. Mubaraki, Shadi Sulaiman, Fahad Algahtani, Rewaida Abdel-Gaber, Esam M. Al-Shaebi, Saleh Al-QuraishyAbstractDue to the endless emergence of drug resistant pathogens, there is a constant need for new therapeutic agents for clinical use. The identification of active components in natural products and determining the efficacy of these active components has become the current focus of pharmacological research. The present study aimed to evaluate the anthelmintic and...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 2 December 2019Source: Saudi Journal of Biological SciencesAuthor(s): Alfred Ngenge Tamfu, Mathieu Sawalda, Maurice Tagatsing Fotsing, Rufin Marie Toghueo Kouipou, Emmanuel Talla, Godloves Fru Chi, Justin Jacquin Epah Epanda, Joseph Tanyi Mbafor, Tariq Ahmad Baig, Almas Jabeen, Farzana ShaheenAbstractPropolis is rich in diverse bioactive compounds. Propolis samples were collected from three localities of Cameroon and used in the study. Column chromatography separation of propolis MeOH:DCM (50:50) extracts yielded a new isoflavonol, 2-hydroxy-8-prenylbiochanin A (1) alongside 2’,3&rs...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
This study suggests that the formation of METs occurs before pyroptosis (first 6–8 h) and macrophage cell death (up to 24 h), and thus, METs could be included in models describing C. albicans–macrophage interactions. We also observed that macrophage ETosis and phagocytosis can occur simultaneously and that, in the first hours of infection, both processes are similarly important in controlling the proliferation of yeast cells, this being critical in neutropenic patients. Finally, it can also be concluded that, since C. albicans can degrade DNA, the structural component of METs, yeast extracellular DNase activity...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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