Improving breast cancer sensitivity to paclitaxel by increasing aneuploidy Medical Sciences

This study investigates the predictive value of 280 genes encoding proteins that regulate microtubule assembly and function. By analyzing 3 independent multicenter randomized cohorts of breast cancer patients, we identified 17 genes that are differentially regulated in...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research

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Authors: Altundag K PMID: 31786895 [PubMed - in process]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
Contributors : Isabelle Sirois ; Adriana Aguilar-Mahecha ; Josiane Lafleur ; Emma Fowler ; Viet Vu ; Michelle Scriver ; Marguerite Buchanan ; Catherine Chabot ; Aparna Ramanathan ; Banujan Balachandran ; Stephanie Legare ; Ewa Przybytkowski ; Cathy Lan ; Urszula Krzemien ; Luca Cavallone ; Olga Aleynikova ; Cristiano Ferrario ; Marie-Christine Guilbert ; Naciba Benlimame ; Amine Saad ; Moulay Alaoui-Jamali ; Horace Uri Saragovi ; Sylvia Josephy ; Ciara O'Flanagan ; Stephen D Hursting ; Vincent R Richard ; Rene P Zahedi ; Christoph H Borchers ; Eric Bareke ; Sheida Nabavi ; Peter Tonellato ; Josee-Anne Roy ; Andre Robidoux ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Metformin use has been linked to pathologic complete response (pCR) following neoadjuvant chemotherapy for several malignancies. We aimed to investigate the association of diabetes mellitus (DM) and metformin use with pCR in breast cancer.
Source: Journal of Surgical Research - Category: Surgery Authors: Source Type: research
CONCLUSIONS: This study suggested that 'CEX' therapy as NAC could be an important option for individualized treatment. In particular, it was effective for TN breast cancer. PMID: 31776320 [PubMed - as supplied by publisher]
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research
Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer? Int J Oncol. 2019 Nov 25;: Authors: Ritter A, Hirschfeld M, Berner K, Rücker G, Jäger M, Weiss D, Medl M, Nöthling C, Gassner S, Asberger J, Erbes T Abstract Due to the positive association between neoadjuvant chemotherapy (NACT) and the promising early response rates of patients with triple negative breast cancer (TNBC), including probabilities of pathological complete response, NACT is increasingly used in TNBC management. Liquid biopsy‑based biomarkers with the power to ...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
CONCLUSION: Level III positivity rate is high and so cannot be avoided in locally advanced breast cancer following neoadjuvant chemotherapy. None of the preoperative factors predict for level III positivity. Level III positivity in cT3N1 and cT2N2 is low and these subgroups require further studies. PMID: 31755729 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Tags: Ann R Coll Surg Engl Source Type: research
Condition:   Breast Cancer Female Interventions:   Drug: Metformin Hydrochloride 850 mg Tablets;   Drug: AC-T chemotherapy regimen Sponsors:   Damanhour University;   Alexandria University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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