Safety of guselkumab in hepatitis B virus infection.

Safety of guselkumab in hepatitis B virus infection.
Dermatol Online J. 2019 Oct 15;25(10):
Authors: Duncan JR, Orlowski TJ, Elewski BE
Abstract
Reactivation of hepatitis B virus (HBV) following the use of TNF antagonists has been reported and is a contraindication to use of these medications. Although the risk of reactivation of HBV during use of ustekinumab and secukinumab is low in patients with only HBV core antibody positivity, the risk is substantial in patients with chronic HBV infection. Less information is available regarding the use of pure IL-23 antagonists. Herein we discuss the successful treatment with guselkumab of a patient with HBV core antibody positivity, without evidence of HBV reactivation or other liver complications.
PMID: 31735016 [PubMed - in process]

Source: Dermatol Online J - October 14, 2019 Category: Dermatology Authors: Duncan JR, Orlowski TJ, Elewski BE Tags: Dermatol Online J Source Type: research