Development of photo-magnetic drug delivery system by facile-designed dual stimuli-responsive modified biopolymeric chitosan capped nano-vesicle to improve efficiency in the anesthetic effect and its biological investigations

Publication date: Available online 18 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Hongwei Liu, Junfeng Liu, Xianfeng Xie, Xuebin LiAbstractThough anesthetic drug delivery system and drug vehicles is generally applied for pain relief, there are have many difficulties and issues due to its short duration carrier and low biocompatibility, effectiveness at the conditions of inflammation at acidic pH. To resolve this issue, we have designed and developed the dual (pH and temperature) responsive bio-nanomaterial to improve the efficiency anesthetic drug delivery system. Chitosan is a unique class of biomaterials that is widely used in medical devices. The surface engineering of ZnFe2O4 nanoparticles was performed by coating with chitosan using simple precipitation method. Then, multi-active anesthetic drug (Lidocaine) was loaded into nano-ferrite to form a drug delivery vehicle. The prepared drug-vesicle was characterized by using XRD, FTIR, SEM, XPS and TGA analysis. XRD analysis proved the face center cubic structure of zinc nanoferrite. The sustained delivery of Lidocaine (LDC) from CS coated nanoferrite (CS/ZnFe2O4) was stimulated by pH and temperature responsive characteristics of vesicles. The in vitro cytotoxicity of the CS/ZnFe2O4 particles towards fibroblast cells was analyzed by using MTT assay. The drug loaded CS/ZnFe2O4 particles exhibit high biocompatibility and sustained drug release in the physiological pH environment (4.8, 5....
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research

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Publication date: Available online 9 December 2019Source: European Journal of Integrative MedicineAuthor(s): Xiao-Qing Wang, Pei-Bei Duan, Man Zheng, Qian Xu, Li-Hua Yang, A-Qin WangAbstractIntroductionAuricular acupuncture has been used for pain management. A more recent technique which buries an intradermal needle into the skin may provides long lasting stimulation and enhance analgesia. The purpose of this study was to evaluate the efficacy and feasibility of perioperative auricular acupuncture technique via intradermal needling buried on postoperative movement-evoked pain reduction of patients with advanced gastric can...
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Conditions:   Postoperative Pain;   Anesthesia, Regional;   Spinal Stenosis Interventions:   Behavioral: MTP block;   Behavioral: ESP block;   Behavioral: No Block group Sponsor:   Gulhane School of Medicine Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The patient said she was "traumatised" after feeling pain during surgery at Yeovil Hospital last year.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Massage therapy, chiropractic adjustments, herbs and supplements are most commonly recommended
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Internal Medicine, Allergy, Neurology, Nursing, Oncology, Orthopedics, Pharmacy, Psychiatry, Rheumatology, Anesthesiology & amp; Pain, Journal, Source Type: news
CONCLUSION: This study showed that calcitonin could be helpful analgesic agent in different painful situations. Calcitonin can be considered an eligible treatment for acute pains related to vertebral fractures and a feasible alternative for the treatment of the acute and chronic neuropathic pains where other medications might fail. PMID: 31810524 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
ConclusionsIntraoperative events and 1-year postoperative complications were high for both Lichtenstein –Lichtenstein and Laparoscopy–Laparoscopy, and the results therefore support guidelines that recommend another approach at reoperation.
Source: Hernia - Category: Sports Medicine Source Type: research
Motivated by the success of enhanced recovery after surgery (ERAS) protocols in other surgical specialties and the relative contraindications of several typical ERAS interventions in the context of cardiac surgery, Cameron et al. present the findings of a small randomized control trial examining the potential of intraoperative ketamine to reduce both subjective pain scores and opioid consumption in the first 48 hours after coronary artery bypass grafting with left internal mammary artery harvesting.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Furqan A. Maulvi, Lakshmi V. Pillai, Kajal P. Patel, Ankita R. Desai, Manish R. Shukla, Ditixa T. Desai, Hetal P. Patel, Ketan M. Ranch, Shailesh A. Shah, Dinesh O. ShahAbstractLidocaine is widely used as a local anaesthetic in the clinical practice to manage pre- and post-operative pain, skin burns, etc. However, the short duration of action (
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Millions of people with post-traumatic stress disorder (PTSD) — from veterans to rape survivors — have new hope because of a watershed study showing that the injection of an anesthetic to a bundle of nerves in the neck can relieve their symptoms in a clinically significant way. The treatment is known as the stellate ganglion block, or SGB. Used since 1925 for problems such as pain in the arm and shingles, it is safe and effective. In the newly released, eight-week, U.S. Army-funded clinical trial of 108 active-duty service members with PTSD, the nonprofit research institute RTI International found that patients...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Personal PTSD Research Treatment Hyper Vigilance Neuroscience Neurotransmitter Norepinephrine Posttraumatic Stress Disorder pruning Source Type: blogs
Oral mucositis is among the most common tissue toxicities associated with both cytotoxic cancer regimens and head and neck radiotherapy. Current management of oral mucositis might comprise growth factors and cytokines, anti-inflammatory agents, anesthetics, analgesics, antimicrobial and coating agents, cryotherapy and mucosal protectants. Despite its long history and its impact on patients, there are currently no effective options for the prevention or treatment of mucositis. In recent years, more attention has been focused on the role of natural drugs. Verbascoside belongs to the phenylpropanoid glycosides family. Several...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Review Article Source Type: research
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