Effect of tardive dyskinesia on quality of life in patients with bipolar disorder, major depressive disorder, and schizophrenia

ConclusionsThe presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients ’ HRQoL.
Source: Quality of Life Research - Category: Health Management Source Type: research

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Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University. All the patients or their statutory guardians and HC were required to sign an informed consent form.Sample CollectionBlood samples of 52 FES patients and 41 healthy controls were collected from each participant at 08:00 a.m. after overnight fasting. Serum was isolated after centrifuging at 3500 rpm for 10 min, and peripheral blood mononuclear cells (PBMCs) were isolated and stored at –80°C until the biochemistry analysis or RNA was extracted without repeated freezing and thawing.Measurement of Serum OX...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSIONS: This study demonstrates a significant economic burden associated with developing TD, as captured by increased HRU including inpatient admissions and ER visits. PMID: 30638073 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
DiscussionCiliary genes like DRD1 and DRD2 are implicated in neurotransmission and associated with schizophrenia. DRD1 has 4 novel interactors and DRD2 has 12 novel interactors that may have significant role in the pathology of mental disorders. Neuronal pathways associated with cilia interactome with high statistical significance such as dopamine signaling, eNOS signaling, synaptic long-term potentiation pathways are known to be associated schizophrenia. Wnt signaling and PCP signaling are also known to be associated with cilia mediated neurodevelopmental signaling, defects in these pathways contributing to schizophrenia....
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research
This study found that once-daily treatment with valbenazine at 80 mg/day significantly improved the symptoms of tardive dyskinesia compared with placebo in a population of patients with schizophrenia, schizoaffective disorder, or a mood disorder. The med ication was generally well tolerated, even among patients taking concomitant antipsychotics, and the psychiatric status of the patients remained stable throughout the trial.In addition to the article by Sit and colleagues referenced above, the following studies were selected by BBRF in its list of the top advancements and breakthroughs by Foundation grantees in 2017 (in ch...
Source: Psychiatr News - Category: Psychiatry Tags: American Journal of Psychiatry bipolar depression bipolar disorder Brain and Behavior Research Foundation ketamine NEJM Journal Watch Psychiatry rapastinel tardive dyskinesia Source Type: research
Conclusions:Deutetrabenazine provided clinically meaningful improvements in AIMS scores and CGIC regardless of psychiatric illness type, with a favorable safety/tolerability profile.Study Supported by:This study was funded by Teva Branded Pharmaceutical Products R&D, Inc. Petach Tikva, IsraelDisclosure: Dr. Anderson has received personal compensation for activities with LEGATO-HD, AIM-TD, ARM-TD studies. Pride-HD, First-HD, ARC-HD, and Teva CNS> Dr. Factor has received personal compensation for activities with Lundbeck, TEVA, Neurocrine, Avanir, Cynapsus, and Adamas as a consultant and from Uptodate as a speaker. Dr. Fa...
Source: Neurology - Category: Neurology Authors: Tags: Movement Disorders: Huntington ' s Disease and Drug-Induced Dyskinesias Source Type: research
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