Maternal Overweight, Inflammation and Neurological Consequences for the Preterm Child: Results of the ELGAN Study.

Maternal Overweight, Inflammation and Neurological Consequences for the Preterm Child: Results of the ELGAN Study. Geburtshilfe Frauenheilkd. 2019 Nov;79(11):1176-1182 Authors: Brodowski L, Büter W, Kohls F, Hillemanns P, von Kaisenberg C, Dammann O Abstract Maternal overweight and obesity are prenatal risk factors for obstetrical complications, preterm birth, neonatal morbidity as well as cognitive and behavioural developmental disorders in children. Paediatric morbidity and mortality as well as child development disorders are significantly associated with maternal obesity. Particularly in the neurodevelopmental and psychiatric area, it is becoming increasingly clear that, in children of mothers with an increased body mass index (BMI), there is a high correlation with childhood cognitive disabilities, attention disorders, and diseases on the autistic spectrum. The ELGAN (Extremely Low Gestational Age Newborn) study is a multicentre study which has been supported since 2000 by the National Institutes of Health (NIH) and whose objective is to research predictors for neonatal brain damage and neurological-cognitive sequelae in premature infants. The areas of focus are the connection between maternal overweight and obesity and pregnancy complications, APGAR scores and systemic inflammatory markers. In this overview, our aim is to summarise the work in this area and discuss it critically on the basis of current literature. We will examine the hypothesis ...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

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ConclusionBreast pilonidal sinus is an extremely rare variant of the condition. It should be suspected on clinical examination. Surgical excision is the definitive treatment strategy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionGiven the increasing number of such surgeries performed the recognition of acute and chronic complications, and their optimal management is of great importance. Although performing a Roux-en-Y fistulojejunostomy was recommended in the literature, conservative and endoscopic treatment should be considered before.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 9 December 2019Source: Cirugía Española (English Edition)Author(s): Jaime Ruiz-Tovar, Raquel Sanchez-Santos, Ester Martín-García-Almenta, Esther García Villabona, Artur Marc Hernandez, Alberto Hernández-Matías, José Manuel Ramírez, Grupo de Trabajo de Cirugía Bariátrica del Grupo Español de Rehabilitación Multimodal (GERM)AbstractEnhanced recovery after surgery (ERAS) protocols are care programs based on scientific evidence and focused on postoperative recovery. They encompass all aspects of patient...
Source: Cirugia Espanola - Category: Surgery Source Type: research
Conclusions: The LEnS concept is a practical refinement to the exposome that accounts for total exposures during particular windows of susceptibility in target organ systems. Application of the LEnS framework in risk assessment and regulation will improve protection of children’s health by enhancing protection of sensitive developing organ systems that are critical for lifelong health and well-being. https://doi.org/10.1289/EHP1250 Received: 19 October 2016 Revised: 08 March 2017 Accepted: 04 April 2017 Published: 07 August 2017 Please address correspondence to E.M. Faustman, Dept. of Environmental and Occupati...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
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Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
This article provides an overview of public health efforts by the U.S. Environmental Protection Agency (EPA) during the past two decades to protect children’s health from environmental hazards. It highlights examples of concrete steps and accomplishments toward improving environmental protection and health outcomes achieved through public policy, rules and regulations, increased scientific understanding, and public health messaging. Additionally, examples of future challenges for better understanding and improving children’s environmental health are discussed. Citation: Firestone M, Berger M, Foos B, Etzel R....
Source: EHP Research - Category: Environmental Health Authors: Tags: Perspectives Brief Communications Children's Health December 2016 Source Type: research
Discussion Klinefelter syndrome (KS) is a common genetic abnormaly with a prevalence of 1 in ~650 male births. It was first described in 1942 by Dr. Harry Klinefelter. It is associated with at least one extra X chromosome with the most common karyotype (~80% of patients) being 47 XXY. Other karyotypes are seen along with mosaicism. It is believed that although it is very prevalent, only about 25-33% of people with KS are identified. About 10% are identified before puberty with the rest usually identified because of hypogonadism and tall stature especially in teenage years or due to infertility in adulthood. KS is diagnosed...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Conclusions Patterns of disease are changing rapidly in LMICs. Pollution-related chronic diseases are becoming more common. This shift presents a particular problem for children, who are proportionately more heavily exposed than are adults to environmental pollutants and for whom these exposures are especially dangerous. Better quantification of environmental exposures and stepped-up efforts to understand how to prevent exposures that cause disease are needed in LMICs and around the globe. To confront the global problem of disease caused by pollution, improved programs of public health monitoring and environmental protecti...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication March 2016 Source Type: research
CONCLUSIONS: Maternal prepregnancy obesity and maternal diabetes in combination were associated with increased risk for ASD and ID. ASD with ID may be etiologically distinct from ASD without ID.
Source: PEDIATRICS - Category: Pediatrics Authors: Tags: Developmental/Behavioral Pediatrics, Autism/ASD Article Source Type: research
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Source: Nutricion Hospitalaria - Category: Nutrition Authors: Tags: Nutr Hosp Source Type: research
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