Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans - Garc ía-Guerrero IA, Cárcamo-Noriega E, Gómez-Lagunas F, González-Santillán E, Zamudio FZ, Gurrola GB, Possani LD.

Every year in Mexico, around 300,000 people suffer from accidents related to scorpion stings. Among the scorpion species dangerous to human is Centruroides ornatus, whose venom characterization is described here. From this venom, a total of 114 components ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

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Contributors : K Burleigh ; D B StetsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we demonstrate that the SIDSP induces a broad and potent antiviral response that is abrogated by treatment with the DNA-PK inhibitor, Nu7441.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Human skin harbors a diverse group of microorganism that form complex communities and involve in a variety of complex molecular and cellular processes inside and outside the skin [1], and even influence gene expression in skin [2]. These microbiota interact directly with skin cells and play a central role in skin physiology and disease [3]. Many of evidence suggest a role for microorganisms in noninfectious skin diseases, such as atopic dermatitis (AD), rosacea, psoriasis, and acne [4]. However, the origin of many skin diseases is multifactorial and in some cases, such as the sensitive skin syndrome (SS), the role of micro...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
In conclusion, increased oxidative stress underlies the decrease in antioxidant capacities and mitochondrial dysfunction in HG environment correlate with inflammation response and apoptosis via ERK1/2-PI3K/Akt-IRF3 pathway in keratinoctes.
Source: Life Sciences - Category: Biology Source Type: research
Abstract Type I interferons (IFNs) facilitate cancer immunosurveillance, antitumor immunity and antitumor efficacy of conventional cell death-inducing therapies (chemotherapy/radiotherapy) as well as immunotherapy. Moreover, it is clear that dendritic cells (DCs) play a significant role in aiding type I IFN-driven immunity. Owing to these antitumor properties several immunotherapies involving, or inducing, type I IFNs have received considerable clinical attention, e.g., recombinant IFNα2 or agonists targeting pattern recognition receptor (PRR) pathways like Toll-like receptors (TLRs), cGAS-STING or RIG-I/MDA...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
Sustaining a kissing bug bite may lead to Chagas disease or allergic reactions. In this article, learn about the symptoms, risks, and treatments associated with kissing bug bites.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Bites and Stings Source Type: news
ConclusionWe report a second case of tsutsugamushi disease with multi-organ dysfunction syndrome and immune thrombocytopenia, which resolved after treatment and extensive care.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
In conclusion, HSV-2 reprogramming opens up DCs for HIV-1 infection and creates a microenvironment favoring HIV-1 transmission.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Correction: Deficiency of the AIM2-ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection. J Immunol. 2019 Dec 06;: Authors: Yan S, Shen H, Lian Q, Jin W, Zhang R, Lin X, Gu W, Sun X, Meng G, Tian Z, Chen ZW, Sun B PMID: 31811018 [PubMed - as supplied by publisher]
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
By YOLONDA Y. WILSON, PhD Last week a nurse posted a video of herself on Twitter mocking patients with the caption “We know when y’all are faking” followed by laughing emojis. Twitter responded with the hashtag #patientsarenotfaking, created by Imani Barbarin, and a slew of testimonials of negligent medical care. While the nurse’s video was not explicitly racialized, plenty in the black community felt a particular sting: there is clear evidence that this attitude contributes to the problem of black patients receiving substandard care, and that negative behavioral traits&n...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients racial bias The OpEd Project Yolonda Wilson Source Type: blogs
Upon binding to pathogen or self-derived cytosolic nucleic acids cyclic GMP-AMP synthase (cGAS) triggers the production of cGAMP that further activates transmembrane protein STING. Upon activation STING translocates from ER via Golgi to vesicles. Monogenic STING gain-of-function mutations cause early-onset type I interferonopathy, with disease presentation ranging from fatal vasculopathy to mild chilblain lupus. Molecular mechanisms underlying the variable phenotype-genotype correlation are presently unclear. Here, we report a novel gain-of-function G207E STING mutation causing a distinct phenotype with alopecia, photosens...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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