Cellular calpain proteases can cleave the enteroviral polyprotein

(University of Jyv ä skyl ä - Jyv ä skyl ä n yliopisto) Enteroviruses can cause severe diseases such as encephalitis or myocarditis, and have been associated with chronic diseases such as type 1 diabetes. In her dissertation at the University of Jyvaskyla M.Sc Mira Laajala focuses on viral and host cell factors that promote the infection of enterovirus B species after cell entry. The research showed that in addition to enteroviral proteases, cellular calpain proteases can cleave the enteroviral polyprotein. The information may possibly be used in antiviral development.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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