Autophagy-endoplasmic reticulum stress inhibition mechanism of superoxide dismutase in the formation of calcium oxalate kidney stones.

CONCLUSION: Enhanced SOD activity can protect the kidneys by reducing autophagy-ERS response and CaOx kidney stone formation. Atorvastatin may be a new option for the prevention and treatment of nephrolithiasis. PMID: 31733571 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research

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ConclusionEnhanced SOD activity can protect the kidneys by reducing autophagy-ERS response and CaOx kidney stone formation. Atorvastatin may be a new option for the prevention and treatment of nephrolithiasis.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Background Although intestinal and urinary microbiome perturbations are associated with nephrolithiasis, whether antibiotics are a risk factor for this condition remains unknown. Methods We determined the association between 12 classes of oral antibiotics and nephrolithiasis in a population-based, case–control study nested within 641 general practices providing electronic health record data for>13 million children and adults from 1994 to 2015 in the United Kingdom. We used incidence density sampling to match 25,981 patients with nephrolithiasis to 259,797 controls by age, sex, and practice at date of diagnosis (in...
Source: Journal of the American Society of Nephrology : JASN - Category: Urology & Nephrology Authors: Tags: Clinical Epidemiology Source Type: research
We have read the article “Impact of statin Intake on Kidney Stone Formation” by Chen AJ., et al., with utmost interest. The authors presented the effects of statins on nephrolithiasis risk and higher lipids correlation with risk of stone formation1. We would like to request the authors to elucidate the following points for our better understanding.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Letters to the Editor Source Type: research
We have read the article “Impact of statin intake on kidney stone formation” by Cohen et al, with utmost interest. The authors presented the effects of statins on nephrolithiasis risk and higher lipids correlation with risk of stone formation.1 We would like to request the authors to elucidate the following points for our better understanding.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Letters to the Editor Source Type: research
To determine whether statin intake affects nephrolithiasis risk, and whether higher lipid levels correlate with stone risk. Dyslipidemia is a known independent risk factor for urolithiasis, and emerging evidence suggests common biological pathways. Previous work has suggested that statins protect against new stone formation, but these findings have not been verified by other investigators.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Endourology and Stones Source Type: research
ConclusionsOur study revealed that atorvastatin has decreasing effect on UUa levels, whereas increasing effect on UCa levels. We think it cannot certainly be deduced that atorvastatin could be beneficial on overall urinary metabolic risk factors. Contrarily, atorvastatin may lead to an increased risk of calcium stones, but when considering its UUa decreasing effect, it may help in reducing the uric acid stone recurrence.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
BY SHANNON BROWNLEE On Wednesday, October 25, 2017 I was at the inaugural Society for Participatory Medicine conference. It was a fantastic day and the ending keynote was the superb Shannon Brownlee. It was great to catch up with her and I’m grateful that she agreed to let THCB publish her speech. Settle back with a cup of coffee (or as it’s Thanksgiving, perhaps something stronger), and enjoy–Matthew Holt George Burns once said, the secret to a good sermon is to have a good beginning and a good ending—and to have the two as close together as possible. I think the same is true of final keynotes aft...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: OP-ED Patients Physicians Lown Institute Overtreatment Right Choice Alliance Shannon Brownlee Society for Participatory Medicine Source Type: blogs
My new book, Undoctored: Why Health Care Has Failed You and How You Can Become Smarter Than Your Doctor, hits bookstores today, May 9th, 2017. I will be hosting a Facebook LIVE event today, also, at 5 pm Eastern/4 pm Central/3 pm Mountain/2 pm Pacific. I want Undoctored to spark a revolution, a revolt against the healthcare system and its predatory ways. Undoctored sums up the lessons learned from the six years of the worldwide Wheat Belly experience that witnessed hundreds of thousands, even millions, of people achieve slenderness and health. Undoctored expands the discussion to show readers how even greater levels of hea...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored costs drugs grains health healthcare medical devices medicines wheat Source Type: blogs
A study of 100,000 patients with hyperlipidemia compared statin users with nonusers and found that statin use reduced the risk for stones. Medscape Medical News
Source: Medscape Urology Headlines - Category: Urology & Nephrology Tags: Urology News Source Type: news
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