The Use of Nanoparticles to Guide the Surgical Treatment of Prostate Cancer

Condition:   Prostate Cancer Interventions:   Drug: (64Cu)-labeled PSMA-targeting particle tracer, or 64Cu-NOTA-PSMAi-PEG-Cy5.5-C' dots;   Diagnostic Test: PET/MRI;   Other: Blood and urine sampling;   Procedure: laparoscopic radical prostatectomy and bilateral pelvic LN dissection Sponsors:   Memorial Sloan Kettering Cancer Center;   Elucida Oncology;   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

Related Links:

Authors: Bratu OG, Diaconu CC, Mischianu DLD, Constantin T, Stanescu AMA, Bungau SG, Ionita-Radu F, Marcu RD Abstract Prostate cancer is the second most common form of cancer in men in Europe. The primary treatment of this type of cancer is radical prostatectomy, which has shown good oncological results. Radical prostatectomy (open, laparoscopic or robotic) has high success and low morbidity rates in patients with localized prostate cancer. The life expectancy is>10 years after radical prostatectomy. Studies have shown that ~20%-30% of the patients who have undergone radical prostatectomy can develop biochemical...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Robot-assisted laparoscopic radical prostatectomy (RALRP) is one of the treatment options for localized prostate cancer, with an excellent disease control rate. However, these patients can experience late disease recurrence with metastatic dissemination. Peritoneal metastases are an uncommon recurrence site. Here, we discuss three cases of peritoneal metastases following RALRP and the mechanisms of peritoneal invasion. Through a literature review and our case reports, we postulate the existence of two distinct mechanisms of peritoneal invasion: one being iatrogenic, following a laparoscopic surgery with a well differentiat...
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Publication date: December 2019Source: European Urology Supplements, Volume 18, Issue 12Author(s): David Nikoleishvili, Givi Koberidze, Zaza Tchanturaia, Ambrosi Pertia
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: LRP showed higher surgical time, less complications and it didn't influence the hospital stay. PMID: 31806247 [PubMed - as supplied by publisher]
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Authors: Tags: Actas Urol Esp Source Type: research
Condition:   Prostate Cancer Interventions:   Drug: (64Cu)-labeled PSMA-targeting particle tracer, or 64Cu-NOTA-PSMAi-PEG-Cy5.5-C' dots;   Diagnostic Test: PET/MRI;   Other: Blood and urine sampling;   Procedure: laparoscopic radical prostatectomy and bilateral pelvic LN dissection Sponsors:   Memorial Sloan Kettering Cancer Center;   Elucida Oncology;   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: The self-reported benefits of physiotherapy for SUI symptoms did not differ significantly between the two types of prostatectomy surgery at 2 years post-surgery. PMID: 31719716 [PubMed]
Source: Physiotherapy Canada - Category: Physiotherapy Authors: Tags: Physiother Can Source Type: research
Retzius-sparing robot-assisted laparoscopic radical prostatectomy (rsRARP) allows entire prostatectomy procedure via the pouch of Douglas. In low- and intermediate-risk prostate cancer (PCa) there is level 1 e...
Source: BMC Urology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
CONCLUSIONS: We developed and externally validated a nomogram to predict LNI in patients treated with RALP from a prospective, multi-institutional, nationwide series. A risk of LNI> 7% is proposed as cut-off above which e-PLND is recommended. PMID: 31727561 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
ConclusionsOur findings suggest that patients who underwent RALRP with HIV did not experience higher risk of potentially life-threatening postoperative complications. RALRP could be safely considered as a surgical treatment for HIV(+) patients with prostate cancer.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Rationale: Robot-assisted laparoscopic prostatectomy (RALP) is the most frequent strategy used for the surgical remedy of patients with localized prostate cancer. Although there is awareness about potential patient positioning nerve injuries, iatrogenic nerve lesions are less described in the literature. Here, we report 3 cases of patients who presented with neuropathic painful complications due to RALP-associated nerve lesions. Patient concerns: A 62-year-old patient (case 1), a 72-year-old male (case 2), and a 57-year-old patient (case 3) presented at the clinic with symptoms of neuropathic pain after RALP surgery. ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
More News: Cancer | Cancer & Oncology | Laparoscopy | Nanotechnology | Prostate Cancer | Prostatectomy | Research