Novel Form of Acquired Long QT Syndrome

Conditions:   Long QT Syndrome;   Connective Tissue Diseases;   Rheumatoid Arthritis Intervention:   Drug: Prednisone Sponsors:   Narrows Institute for Biomedical Research;   VA New York Harbor Healthcare System Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conditions:   Long QT Syndrome;   Connective Tissue Diseases;   Rheumatoid Arthritis Intervention:   Drug: Prednisone Sponsors:   Narrows Institute for Biomedical Research;   VA New York Harbor Healthcare System Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion The data are first to show that systemic inflammation via elevated IL-6 levels may represent a novel QT-prolonging risk factor contributing to TdP occurrence in the presence of other classical risk factors. If confirmed, this could open new avenues in antiarrhythmic therapy.
Source: Heart - Category: Cardiology Authors: Tags: Arrhythmias and sudden death Source Type: research
Abstract A 91-year-old woman presented to the emergency department by ambulance after her family found her minimally responsive. Telemetry monitoring demonstrated episodes of non-sustained polymorphic ventricular tachycardia (PMVT) associated with significantly prolonged repolarization. Her medical history revealed that she was taking quinine or a derivative in three different forms: hydroxychloroquine, quinine sulfate (for leg cramps), and her gin mixed with tonic water (containing quinine). The present case is illustrative of classic etiologies and findings of acquired long QT syndrome, and serves as an importan...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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