Unusual Presentation of Myeloid Sarcoma in a Patient With Usher Syndrome
A 45-year-old woman with Usher syndrome, associated congenital deafness, progressive blindness due to retinitis pigmentosa, and latent autoimmune diabetes presented to the emergency department with malaise, dizziness, and pelvic pain following removal of an intrauterine device. A posterior vaginal wall mass was found on examination. Laboratory values demonstrated anemia, thrombocytopenia, and an elevated white blood cell count, raising concern for infection and potential onset of diabetic ketoacidosis. This prompted a peripheral blood smear review, which showed 60% monocytic blasts. A subsequent vaginal mass biopsy showed a myeloid sarcoma. Molecular studies demonstrated an NPM1 mutation in exon 12 without FLT3 mutation or internal tandem duplication. While a diagnosis of acute myeloid leukemia with mutated NPM1 was considered, cytogenetics revealed a complex karyotype with evidence of clonal evolution, consistent with acute myeloid leukemia with myelodysplasia-related changes. In addition to an unusual presentation of myeloid sarcoma, this case posed significant questions regarding management and pursuit of hematopoietic stem cell transplantation. Usher syndrome is genetically and clinically heterogeneous. While it is not known to be associated with increased risk of malignancy, mutation of genes associated with Usher syndrome has been identified in acute leukemia. Our case raises the question as to whether potential germline predisposition should be considered in a patient ...
Authors: Bagheri Z, Labbani-Motlagh Z, Mirjalili M, Karimzadeh I, Khalili H Abstract Cytopenia is common complication in critically ill patients. Aim: Incidence and pattern of different types of cytopenia as well as its impact on mortality and length of stay in critically ill patients were evaluated. Methods: Critically ill patients with any kind of cytopenia for more than 2 days were evaluated. Results: Anemia was the most common type of cytopenia in the patients (99.14%), followed by lymphocytopenia (32.17%), thrombocytopenia (27.82%), and leukopenia (19.13%). Mortality rate was significantly higher in patients with anemia (p
CONCLUSION: Data suggest different roles of opioidergic system and their antagonist in pain control and mood in PTSD. However, further investigations need to be done in order to reveal the role of endogenous opioidergic system and opioidergic antagonist system as a mediator in PTSD patients suffering from acute or chronic pain. PMID: 32492768 [PubMed - as supplied by publisher]
CONCLUSIONS: MSG administered parenterally to the higher dose to adult rats affects the immunoreactivity of S100β protein in PAG. Phenotypic changes of the studied cells may indicate reactivity of glial cells and increased expression of the studied protein whereas a decrease in their number may result from the increased protein secretion into the extracellular space or cytotoxic death of glial cells. PMID: 32495938 [PubMed - as supplied by publisher]
LUNG CANCER symptoms include difficulty breathing, headaches, and persistent chest pain. But you could also be at risk of an advanced tumour if you develop a subtle sign on your eyes. Could you be at risk of lung cancer?
Publication date: Available online 13 May 2020Source: Molecular MetabolismAuthor(s): Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant
Publication date: Available online 4 June 2020Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yannis V. Simos, Konstantinos Spyrou, Michaela Patila, Niki Karouta, Haralambos Stamatis, Dimitrios Gournis, Evangelia Dounousi, Dimitrios Peschos
Publication date: Available online 5 June 2020Source: Journal of Geriatric OncologyAuthor(s): Smith Giri, Madan Raj Aryal, Han Yu, Alyssa Grimshaw, Ranjan Pathak, Scott P. Huntington, Binod Dhakal
Publication date: Available online 4 June 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Losser Marie-Reine, Lapoix Coline, Delannoy Matthieu, Champigneulle Benoit, Payen Didier
Publication date: Available online 4 June 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Michael Cardinale, Pierre Esnault, Jean Cotte, Pierre J Cungi, Philippe Goutorbe
Authors: García-Caballero L, Caneiro J, Gándara M, González-Ortega N, Cepeda-Emiliani A, Gude F, Collado M, Beiras A, Gallego R Abstract Merkel cells are neuroendocrine cells associated to a neural sensitive ending and localized primarily in the epidermis, although they are also found in oral mucosa. Sox2 or SRY-box2 is a key transcription factor important in the maintenance of embryonic neural crest stem cell pluripotency. Sox2 has been described in Merkel cells of skin and in Merkel cell carcinomas, but not specifically in oral Merkel cells. The aims of the present study were to analyze the d...
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