Giant Cell-rich Tanycytic Ependymoma as Intramedullary Spinal Mass

We describe the morphologic features of a diagnostically challenging intramedullary spinal cord tumor masquerading as a high grade lesion due its cellular composition and discuss its differentials. The report also emphasizes the role of already established and recently introduced immunohistochemical markers and other ancillary techniques as useful adjuncts in the diagnosis.
Source: Neurology India - Category: Neurology Authors: Source Type: research

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This article gives an overview o f the recent advances in the diagnostic/prognostic potential of miRNAs in a selection of pediatric CNS tumors: medulloblastoma, ependymoma, pilocytic astrocytoma, glioblastoma, diffuse intrinsic pontine glioma, atypical teratoid/rhabdoid tumors, and choroid plexus tumors.
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
ConclusionsWe report actionable targets, including frequentFGFR1 mutation in optic-pathway PA that makes them excellent candidates to anti-FGFR therapies, andBRAF non-canonical mutations in PA.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
AbstractObjective5-Aminolevulinic acid (5-ALA) –guided resection of gliomas in adults enables better delineation between tumor and normal brain, allowing improved resection and improved patients’ outcome. Recently, several reports were published regarding 5-ALA for resection of pediatric brain tumors. The aim of the study was to determine th e intracellular fluorescence of protoporphyrin IX (PPIX) in pediatric brain tumors by hyperspectral imaging and to compare it with visually observed intraoperative fluorescence.Methods5-ALA was administered orally 4  h prior to surgery. During tumor resection, the surg...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Abstract Being the fourth leading cause of cancer-related death, glial tumors are highly diverse tumor entities characterized by important heterogeneity regarding tumor malignancy and prognosis. However, despite the identification of important alterations in the genome of the glial tumors, there remains a gap in understanding the mechanisms involved in glioma malignancy. Previous research focused on decoding the genomic alterations in these tumors, but due to intricate cellular mechanisms, the genomic findings do not correlate with the functional proteins expressed at the cellular level. The development of mass sp...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Conclusion5-ALA could play a role in resection of pediatric brain tumors. However, further prospective clinical trials are needed.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
AbstractPurpose of ReviewTemozolomide is a first-line treatment for newly diagnosed glioblastoma. In this review, we will examine the use of temozolomide in other contexts for treating gliomas, including recurrent glioblastoma, glioblastoma in the elderly, diffuse low- and high-grade gliomas, non-diffuse gliomas, diffuse intrinsic pontine glioma (DIPG), ependymoma, pilocytic astrocytoma, and pleomorphic xanthoastrocytoma.Recent FindingsTemozolomide improved survival in older patients with glioblastoma, anaplastic gliomas regardless of 1p/19q deletion status, and progressive ependymomas. Temozolomide afforded less toxicity ...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
ConclusionH3 K27M mutations are frequent in adult midline gliomas and have a prognostic role similar to H3 K27M wild-type high-grade tumors.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: H3 K27M mutations are frequent in adult midline gliomas and have a prognostic role similar to H3 K27M wild-type high-grade tumors. PMID: 30610375 [PubMed - as supplied by publisher]
Source: Clin Med Res - Category: Research Authors: Tags: J Cancer Res Clin Oncol Source Type: research
Conclusions: In our practice we found thrombin-gelatin hemostatic matrix sealant to be a valid and safe tool for strengthening hemostasis in pediatric low-grade posterior fossa surgery.Pediatr Neurosurg
Source: Pediatric Neurosurgery - Category: Neurosurgery Source Type: research
AbstractCentral nervous system neoplasms are the most common solid tumours that develop in children, with the greatest proportion located in the infratentorium. The 2016 World Health Organization Central Nervous System tumour classification evolved from the 2007 edition with the integration of molecular and genetic profiling into the diagnosis, the addition of new entities and the removal of others. Radiology can assist with the subtyping of tumours from certain characteristics described below to provide prognostic information and guide further management. The latest insights into the radiologic characteristics of these po...
Source: Pediatric Radiology - Category: Radiology Source Type: research
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