Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia coli or Klebsiella pneumoniae

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Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: ESPID Reports and Reviews Source Type: research

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We reported a general increase of unnecessary urine cultures in both community and hospital patients. The most representative microorganism isolated from Community (58.2%) and Hospital (47.6%) was E. coli. UTIs causative bacteria in hospitalized patients was more than twice as resistant to Trimetoprim/sulphamethoxazole (OR 2.26) and Imipenem (OR 2.56), for Gram-positive and Gram-negative, respectively, than in Community patients. Nitrofurantoin was the only agent without differences in resistance rate between community and hospital UTIs. Therefore, physicians could use it as a definitive therapy for uncomplicated cystitis ...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
We investigated antimicrobial resistance trends and characteristics of ESBL-producing Escherichia coli isolates from pets and whether this correlates with antibiotic usage in the clinic. Clinical samples containing E. coli from diseased cats and dogs were screened for antibiotic sensitivity and associated genotypic features. We identified 127 E. coli isolates from 1886 samples from dogs (n = 1565) and cats (n = 321) with the majority from urinary tract infections (n = 108, 85%). High rates of resistance were observed for β-lactams and fluoroquinolones and resistance to> 3 antibiotic classes (MDR) increased from 67%...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionsUrinary IL-1 β levels might be a useful tool to identify patients with challenging MDR bacterial infections.
Source: Inflammation Research - Category: Research Source Type: research
Urinary tract infections (UTIs) are the most common infectious diseases, and Escherichia coli is the most common pathogen isolated from patients with UTIs. The products of sfa, afa and foc genes are important for...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
AbstractPurposeCatheter-associated urinary tract infections (CAUTIs) are a significant cause of morbidity worldwide, as they account for 40% of all hospital-associated infections. Microbial biofilm formation on urinary catheters (UCs) limits antibiotic efficacy, making CAUTI extremely difficult to treat. To gain insight into the spatiotemporal microbe interactions on the catheter surface we sought to determine how the presence or absence of bacteriuria prior to catheterization affects the organism that ultimately forms a biofilm on the UC and how long after catheterization they emerge.MethodsThirty UCs were collected from ...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
In this study, we collected 326 samples from cases with UTIs or other urinary system diseases at the China Agricultural University Veterinary Teaching Hospital, Beijing, from 2016–2018. In total, 129 non-duplicate bacterial isolates were recovered from 103 clinical samples. The proportion of positive female samples was higher than that of males. The predominant Gram-negative bacteria were Escherichia coli and Klebsiella spp., while Staphylococcus spp. were the predominant Gram-positive bacteria. Broth microdilution-based antimicrobial susceptibility testing showed that 39% of E. coli and 51.5% of Staphylococcus spp. ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 30 November 2019Source: Journal of Microbiological MethodsAuthor(s): Jolanda K. Brons, Stefanie N. Vink, Marjon G.J. de Vos, Stefan Reuter, Ulrich Dobrindt, Jan Dirk van ElsasAbstractUropathogenic Escherichia coli (UPEC) is the most common causal agent of urinary tract infections (UTIs) in humans. Currently, clinical detection methods take hours (dipsticks) to days (culturing methods), limiting rapid intervention. As an alternative, the use of molecular methods could improve speed and accuracy, but their applicability is complicated by high genomic variability within UPEC strains. Here, w...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
In conclusion, this model allows for longitudinal imaging of host responses to localized kidney challenges and highlights the extensive network of renal phagocytes and their behavior in vivo in health and disease.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionHigh prescribing rates for amikacin and penicillins (± β-lactamase inhibitors) and prolonged i.v. treatments were observed. Escherichia coli was highly resistant to ampicillin, whilst third-generation cephalosporins exhibited greater in vitro efficacy. Establishment of antimicrobial stewardship programmes and regular monitoring of antimicrobial resistance could help to minimise inappropriate prescribing for UTIs.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Conclusions Oral antimicrobial agents have a limited role as empiric treatment of UTIs due to antibiotic-resistant Enterobacteriales species, with the exception of nitrofurantoin for E. coli including ESBL-producing strains. Oral cephalosporins were the second most susceptible agents to E. coli.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Original Articles Source Type: research
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