Measuring influenza hemagglutinin (HA) stem-specific antibody-dependent cellular cytotoxicity (ADCC) in human sera using novel stabilized stem nanoparticle probes.

CONCLUSION: We report on an assay to measure stem-specific ADCC activity using SS np probes. Our results indicate high prevalence of HA-stem antibodies with cross-reactive ADCC activity. Such assay could be utilized in the assessment of next generation influenza vaccines. PMID: 31735504 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31735504?dopt=Abstract

Source: Vaccine - November 13, 2019 Category: Allergy & Immunology Authors: Smatti MK, Nasrallah GK, Al Thani AA, Yassine HM Tags: Vaccine Source Type: research