Priming with MF59 adjuvanted versus nonadjuvanted seasonal influenza vaccines in children - A systematic review and a meta-analysis.
CONCLUSIONS: Two doses of adjuvanted IIV consistently induced better humoral immune responses against Type A and B influenza viruses compared with nonadjuvanted IIVs in young children, particularly among those 6-35 months. One adjuvanted IIV dose had a similar response to two nonadjuvanted IIV doses against Type A influenza viruses. Longer-term benefits from imprinting and cell-mediated immunity, including trials of clinical efficacy, are gaps that warrant investigation.
PMID: 31735505 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Patel MM, Davis W, Beacham L, Spencer S, Campbell AP, Lafond K, Rolfes M, Levine MZ, Azziz-Baumgartner E, Thompson MG, Fry AM Tags: Vaccine Source Type: research
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