Serial scanning with 99m Tc-3, 3-diphosphono-1, 2-propanodicarboxylic acid ( 99m Tc-DPD) for early detection of cardiac amyloid deposition and prediction of clinical worsening in subjects carrying a transthyretin gene mutation

Conclusions99mTc-DPD scan detects cardiac involvement in subjects with TTR gene mutation earlier than ECG, echocardiography and biochemical markers, occurring some years before the fulfillment of current diagnostic criteria for cardiac amyloidosis. A positive99mTc-DPD scan predicts cardiac symptoms onset.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research