Alterations Of Glycerophospholipid And Fatty Acyl Metabolism In Multiple Brain Regions Of Schizophrenia Microbiota Recipient Mice
Conclusion: Our results demonstrated that a significant percentage of patients affected by both mood disorders and schizophrenia shows relevant social dysfunction. Social dysfunction is related, but not completely explained by psychopathological severity. In several patients, it tends to persist also during remission state. Socio-demographic and lifestyle factors were also found to play a role and should therefore be taken into consideration in further studies investigating social dysfunction.
People receiving treatment for schizophrenia and bipolar disorder may experience a gradual loss of cognitive function -- including declines in verbal skills -- over the course of their illness, according to new research.
CONCLUSIONS: This study, in line with previous studies, shows that a diagnosis of T1DM is associated with a decreased risk of schizophrenia. This finding of an inverse association between T1DM and schizophrenia may bring an interesting piece, related to autoimmunity, into the schizophrenia-aetiology puzzle. PMID: 31816222 [PubMed - as supplied by publisher]
ConclusionHere, we examined the psychometric properties of a comprehensive social cognition battery based on the SCOPE study in an Asian schizophrenia population. Continued evaluation and standardization of social cognitive measures are needed to refine our understanding of this construct in schizophrenia.
AbstractCannabidiol (CBD), a non-psychotropic cannabinoid, demonstrates antipsychotic-like and procognitive activities in humans and in animal models of schizophrenia. The mechanisms of these beneficial effects of CBD are unknown. Here, we examined behavioral effects of CBD in a pharmacological model of schizophrenia-like cognitive deficits induced by repeated ketamine (KET) administration. In parallel, we assessed transcriptional changes behind CBD activities in the prefrontal cortex (PFC), the main brain area linked to schizophrenia-like pathologies. Male Sprague-Dawley rats were injected for 10 days with KET followed by...
Molecular Psychiatry, Published online: 11 December 2019; doi:10.1038/s41380-019-0623-xTransplantation of mesenchymal stem cells causes long-term alleviation of schizophrenia-like behaviour coupled with increased neurogenesis
Individuals over age 60 with schizophrenia who were prescribed long-acting injectable (LAI) antipsychotics after being discharged from a hospital were significantly less likely to be rehospitalized within a year than those receiving oral antipsychotics, according to areport inThe American Journal of Geriatric Psychiatry. Also, patients who did need to be admitted again had a longer time to rehospitalization.LAI antipsychotics have been shown to improve adherence to medication in younger populations, which in turn improves overall outcomes. Yet evidence in older populations is lacking.Risk factors for nonadherence in elderl...
ConclusionsSchizophrenia is featured by disrupted ‘limbic areas-to-thalamus’ rsEC, in contrast with diffusively altered rsFC. Moreover, both rsEC and rsFC contain valuable and complementary information which may be used as diagnostic markers for schizophrenia.
Publication date: Available online 10 December 2019Source: Journal of Psychiatric ResearchAuthor(s): Monalisa Jena, Rajeev Ranjan, Biswa Ranjan Mishra, Archana Mishra, Santanu Nath, Pallabi Sahu, Bikash Ranjan Meher, Anand Srinivasan, Rituparna Maiti
Conditions: Schizophrenia; Schizo Affective Disorder; Bipolar Disorder; Depression Intervention: Other: Wellth - Financial Incentives Sponsor: Northwell Health Recruiting