Nonlinear Relation Between Burst Dorsal Root Ganglion Stimulation Amplitude and Behavioral Outcome in an Experimental Model of Painful Diabetic Peripheral Neuropathy
ConclusionOur findings indicate a nonlinear relationship between Burst ‐DRGS amplitude and behavioral outcome, with an estimated optimal amplitude of 52% MT. Further optimization and analysis of DRGS driven by insights into the underlying mechanisms related to the various stimulation paradigms is warranted.
Condition: Gestational Diabetes Interventions: Other: Meal A; Other: Meal B Sponsor: Massachusetts General Hospital Not yet recruiting
Conditions: Diabetic Macular Edema; Macular Edema; Type 2 Diabetes With Diabetic Macular Edema; Type 1 Diabetes With Diabetic Macular Edema; Diabetic Retinopathy Intervention: Drug: MS-553 Sponsors: Shenzhen MingSight Relin Pharmaceuticals Co., Ltd.; Fountain Medical Development Co., Ltd. Not yet recruiting
Condition: Corneal Abrasion Interventions: Drug: topical tetracaine hydrochloride 1%; Drug: Placebo Sponsor: INTEGRIS Southwest Medical Center Completed
Condition: Neck Pain Interventions: Other: Content Validity; Other: Cultural adaptation Sponsor: Universidade Federal de Pernambuco Active, not recruiting
Condition: Symptomatic Irreversible Pulpitis Interventions: Procedure: Occlusal reduction; Procedure: Sham occlusal reduction Sponsor: Cairo University Completed
Conditions: Pain, Postoperative; Tonsillar Bleeding; Postoperative Nausea and Vomiting Interventions: Drug: Dexamethasone; Drug: Sodium chloride Sponsors: Walid HABRE; University Hospital, Geneva Not yet recruiting
Condition: Pain, Neuropathic Interventions: Procedure: Stellate ganglion block; Procedure: Sham Stellate ganglion block Sponsors: Tanta University; Mohamad Gamal Elmawy, M.D Not yet recruiting
Condition: End Stage Renal Disease Intervention: Other: Presence of elbow pain in patients with end stage renal disease Sponsor: Namik Kemal University Completed
ConclusionsUnder the conditions tested, Con ‐DRGS and Burst‐DRGS are equally effective in attenuating STZ‐induced mechanical hypersensitivity in an animal model of PDPN. Burst‐DRGS showed signs of a residual effect at 15 min after cessation of stimulation, which requires further investigation.