The homeobox factor Irx3 maintains adipogenic identity

Inhibition of Irx3 and Irx5 has been shown to reduce body weight and white adipose tissue (WAT) mass through cell-autonomous and sympathetic-induced increases in adipocyte beiging and thermogenesis in mice and humans. However, the underlying mechanisms of the Irx control over beiging are still largely unknown, as illustrated by recent reports showing divergent effects of Irx3 on adipocyte metabolism and function. Here, we investigated the role of Irx3 in controlling beige preadipocyte function and differentiation.

Source: Metabolism - Clinical and Experimental - November 17, 2019 Category: Biomedical Science Authors: Jan-Inge Bjune, Laurence Dyer, Gro V. R øsland, Karl Johan Tronstad, Pål R. Njølstad, Jørn V. Sagen, Simon N. Dankel, Gunnar Mellgren Source Type: research