Autophagy and Immune-Related Diseases.
Autophagy and Immune-Related Diseases. Adv Exp Med Biol. 2019;1209:167-179 Authors: Tan P, Ye Y, Mao J, He L Abstract Autophagy is an intracellular degradation and recycling machinery by which cellular materials are delivered to the lysosome for disposal. Beyond lysosomal degradation, autophagy genes play additional roles in secretion and membrane-trafficking pathways. Ranging from cell-intrinsic and cell-type-specific regulation of innate inflammatory signaling pathways to intercellular cross talk through secretion of soluble factors (e.g., shaping the MHC immunopeptidome for T cell response, etc.), autophagy exerts multiple functions in driving inflammation and modulating the pathological progression of immune-related disorders such as neurodegenerative diseases, inflammatory bowel diseases, autoimmunity, and metabolic diseases. Notably, owing to the complexity of autophagy process involving multiple proteins and stepwise assembly of protein complexes, noncanonical forms of autophagy or autophagic proteins, which function beyond autophagy, are equally important in the maintenance of cellular homeostasis and pathogenesis. This chapter summarizes the most up-to-date findings of autophagy proteins in the regulation of immune-related diseases. Understanding of the autophagy machinery offers therapeutic strategies for treating inflammatory diseases. PMID: 31728870 [PubMed - in process]
Authors: Pigniczki D, Rutka M, Farkas K, Molnar T PMID: 31818162 [PubMed - as supplied by publisher]
Conclusion: Repeated colonoscopies can be perceived as both an assurance of life and a reminder of a lifelong illness. Healthcare professionals need to provide support in terms of awareness of patients' vulnerability, despite extensive experience of the colonoscopy procedure. For example, person-centred care and continuity in care are potential interventions based on the results of this study. Another important aspect of care is to minimise interference in everyday life to prevent feelings of loss of the healthy self, for example by self-administrated outpatient booking systems.Summarize the established knowledge on this s...
THE EFFECT OF DAILY PHYSICAL ACTIVITY ON THE ACTIVITY OF INFLAMMATORY BOWEL DISEASES IN THERAPY-FREE PATIENTS. Acta Clin Croat. 2019 Jun;58(2):202-212 Authors: Holik D, Včev A, Milostić-Srb A, Salinger Ž, Ivanišević Z, Včev I, Miškulin M Abstract It has been suggested that various environmental factors play a very important role in the etiology of inflammatory bowel diseases (IBDs) and that they have a significant effect on the course of these diseases. The aim of this study was to investigate the effect of daily physical activity on the activity of IBDs in therapy-free patients. Thi...
Conclusions: Novel ultrathin SBE may be less painful for CD patients than conventional SBE. PMID: 31818049 [PubMed - as supplied by publisher]
Conclusions: Colorectal stricture had the highest risk for malignant transformation. Earlier initiation of colonoscopic surveillance in UC patients with risk factors for stricture should be considered to prevent stricture formation and further malignant transformation. PMID: 31816674 [PubMed - as supplied by publisher]
(INSERM (Institut national de la sant é et de la recherche m é dicale)) In animals, a vaccine modifying the composition and function of the gut microbiota provides protection against the onset of chronic inflammatory bowel diseases and certain metabolic disorders, such as diabetes and obesity. This research was conducted by the team of Beno î t Chassaing, Inserm researcher at Institut Cochin (Inserm/CNRS/Universit é de Paris), whose initial findings have been published in Nature Communications.
Conditions: Fatigue; Inflammatory Bowel Disease; Ulcerative Colitis; Crohn Disease Intervention: Sponsor: Corporacion Parc Tauli Completed
Conditions: Inflammatory Bowel Diseases; Colon Dysplasia; Ulcerative Colitis; Crohn Colitis; Indeterminate Colitis Interventions: Device: High Definition Colonoscopy; Device: Dye Spraying Chromocolonoscopy Sponsor: Beth Israel Deaconess Medical Center Recruiting