Serum albumin and atrial fibrillation: insights from epidemiological and mendelian randomization studies

In this study, we aim to characterize the nature and magnitude of the prospective association between serum albumin and incident AF in the Atherosclerosis Risk in Communities (ARIC) Study and investigate any causal relevance to the association between them. ARIC Study is a population-based, prospective, cohort study of cardiovascular risk factors in four US communities, initially consisting of 15,792 participants, aged 45 –64 years, recruited between 1987 and 1989 (visit 1). The final sample size was 12,833 in this study. Baseline (visit 1) characteristics were compared between groups using one-way ANOVA test, Chi square test, or Kruskal–Wallis test as appropriate. We used multivariable Cox’ hazard regression models to assess the association between albumin and incident AF. Two-sample Mendelian randomization (MR) based on publicly available summary-level data from genome-wide association studies was used to estimate the causal influence of the serum albumin and incident AF. During a median follow-up of 2 5.1 years, 2259 (17.6%) participants developed incident AF. After multiple adjustment, serum albumin was inversely associated with incidence of AF [HR = 0.90, 95% CI 0.86–0.94, per SD (0.27 g/dL) increase; HR = 0.80, 95% CI 0.71–0.91, Q4 vs. Q1]. In MR analysis, we detected no evidence for a causal relation between serum albumin level and AF in inverse-variance weighted (IVW) method (odds ratio: 0.996, 9...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research

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Authors: Tsujioka S, Nozoe M, Kawano Y, Suematsu N, Kubota T Abstract A 70-year-old woman with situs inversus totalis underwent catheter ablation for atrial fibrillation and atrial flutter. Although her morphologic left atrium (LA) was enlarged, we performed cryoballoon ablation and liner radiofrequency ablation of the cava-tricuspid isthmus without mapping atrial arrhythmias. However, a different form of atrial tachycardia (AT) recurred. We performed catheter ablation a second time using a three-dimensional electroanatomic mapping system. AT was not terminated by the liner ablation at the roof of morphologic LA an...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractPurpose of reviewAtrial fibrillation is the commonest sustained arrhythmia in rheumatic heart disease and is associated with significant morbidity and mortality. In this review, we discuss its epidemiology, natural course and management with special emphasis on recent developments in understanding and treatment of atrial fibrillation in rheumatic heart disease.Recent findingsUse of direct oral anticoagulants appears promising, especially in developing countries where regular coagulation monitoring is a challenge. Also, restoration and maintenance of sinus rhythm in rheumatic atrial fibrillation appear feasible and ...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Atrial fibrillation (AF) is a frequently identified arrhythmia during the course of sepsis. The aim of this narrative review is to assess the characteristics of patients with new-onset AF related to sepsis and the risk of stroke and death, to understand if there is a need for anticoagulation. We searched for studies on AF and sepsis on PubMed, the Cochrane database, and Web of Science, and 17 studies were included. The mean incidence of new-onset AF in patients with sepsis was 20.6% (14.7% in retrospective studies and 31.6% in prospective). Risk factors for new-onset AF included advanced age, white race, male sex, obesity,...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
 This ECG was texted to me with the question" Wellens'? "The computer read was: Atrial Fibrillation, marked ST Elevation. ***Acute MI***The QT interval is short (377 ms, QTc = 399 ms)This is NOT atrial fibrillation: There is sinus arrhythmia with an accelerated junctional rhythm that competes with the sinus node and results in some AV dissociation (no AV block!).  This is completely benign.I responded: This STE with T-wave inversion looks like a normal variant for an African American.  I would check the troponin, but I do not think it is pathologic.Here is the history: The patient wa...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Authors: Wang Z, Korantzopoulos P, Roever L, Liu T Abstract Atrial fibrillation (AF) is the most frequent arrhythmia encountered in clinical practice and is a major health problem associated with remarkable morbidity, mortality and has considerable healthcare costs. Red blood cell distribution width (RDW) reflects the heterogeneity of the volume and size of red blood cells. It is an easily measured and inexpensive index that has been associated with several cardiovascular disease states. Accumulating evidence suggests that RDW is a prognostic marker of AF in various clinical settings. In this article, we review the...
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Condition:   Atrial Fibrillation Intervention:   Other: diagnostic strategy using ECGI Sponsors:   Felipe Atienza;   Universitat Politècnica de València Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractObjectiveTo compare multiple ‐procedure catheter ablation outcomes of a stepwise approach versus left atrial posterior wall isolation (LA PWI) in patients undergoing non‐paroxysmal atrial fibrillation (NPAF) ablation.BackgroundUnfavorable outcomes for stepwise ablation of NPAF in large clinical trials may be attributable to pro ‐arrhythmic effects of incomplete ablation lines. It is unknown if a more extensive initial ablation strategy results in improved outcomes following multiple ablation procedures.Methods222 consecutive patients with NPAF underwent first ‐time ablation using a contact‐force sensing a...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ ELECTROPHYSIOLOGY Source Type: research
CONCLUSIONS: The hybrid, multidisciplinary approach for treatment of AF in safe and in long-term observation very effective treatment method, reducing healthcare burden and could be considered as an alternative therapeutic option especially in patients with persistent AF. PMID: 33021356 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
Abstract Atrial fibrillation (AF) represents the most common arrhythmia and it is associated with increased morbidity and mortality carrying high social costs. Because of its high prevalence, AF is usually managed not only by cardiologists, but also by general practitioners or in the emergency departments. Conventional classification of AF includes "recent-onset AF" defined as an arrhythmia episode of
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
nus Ki H. Chon We developed an algorithm to detect premature atrial contraction (PAC) and premature ventricular contraction (PVC) using photoplethysmographic (PPG) data acquired from a smartwatch. Our PAC/PVC detection algorithm is composed of a sequence of algorithms that are combined to discriminate various arrhythmias. A novel vector resemblance method is used to enhance the PAC/PVC detection results of the Poincaré plot method. The new PAC/PVC detection algorithm with our automated motion and noise artifact detection approach yielded a sensitivity of 86% for atrial fibrillation (AF) subjects while the ...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
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