A Role for B Cells in the Chronic Inflammation Generated by Visceral Fat Tissue

Much of the long-term harm caused by excess visceral fat tissue is due to raised levels of chronic inflammation, the inappropriate over-activation of the immune system characteristic of both obesity and aging. Chronic inflammation accelerates the progression of near all of the common age-related conditions. There are numerous mechanisms via which fat tissue rouses an immune response: cellular debris that triggers immune cells into action; generation of excessive numbers of senescent cells; inappropriate signaling from fat cells that mimics the response to infection; infiltration of inflammatory macrophages into fat tissue; and so forth. Researchers here investigate some of the details of the way in which the immune system interacts with visceral fat, focusing on a role for B cells in spurring the inflammation that results. Previous work found that as people age, their body's ability to generate energy by burning belly fat is reduced. Consequently, fat that surrounds the internal organs increases in the elderly. Researchers had found that the immune cells necessary to the fat-burning process, called macrophages, were still active but their overall numbers declined as belly fat increased with aging. This latest study found that something else is happening as well. Adipose B cells in belly fat unexpectedly proliferated as animals aged, contributing to increased inflammation and metabolic decline. "These adipose B cells are a unique source of inflammation. Normally ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

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This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(CNN) — Should you eat before or after exercise in the morning? The debate has raged for years. The eat-first camp says food before exercise boosts blood sugars, giving the body fuel to increase the intensity and length of a workout. It also keeps you from being fatigued or dizzy. The eat-after camp says you burn more fat if you fast before exercise. A small UK study published Friday supports the latter point of view: In 30 obese or overweight men, those who exercised before breakfast burned twice the fat as men who ate breakfast before they worked out. That’s because exercising with no fuel forces the body to ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Exercise Source Type: news
Abstract BACKGROUND: Body mass index (BMI) is linked to Type 2 diabetes (T2D). Although romantic partners influence each other's health outcomes, it is unclear if partner's BMI is related to the development of T2D. PURPOSE: To test prospective, dyadic associations between BMI and the development of T2D in middle-aged and older adult couples over 8 years. METHODS: Data came from 950 couples in the Health and Retirement Study. Neither partner had diabetes at baseline (2006). The actor-partner interdependence model was used to examine dyadic associations between BMI at baseline and the development of T2D du...
Source: Annals of Behavioral Medicine - Category: Psychiatry & Psychology Authors: Tags: Ann Behav Med Source Type: research
Surely, some things can never be forgiven, should never be forgiven? Susie was 48 years old, and came for counseling for burnout in her highly responsible job. It took three sessions before she trusted me enough to tell me her story. Thirty years before, a man had brutally raped her. She’d spent three weeks in hospital, and has physical handicaps from it to this day. The court hearing was even more traumatizing. He showed no remorse. His story was that she’d initiated contact, invited sex, then backed out at the last minute, hitting him and scratching his face, so he defended himself, and “um… went...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inspiration & Hope Mindfulness Personal Psychotherapy Trauma Violence and Aggression Women's Issues Betrayal Forgiveness self-compassion Source Type: blogs
By Katie Hunt, CNN (CNN) — Drinking coffee could activate the body’s fat-fighting defenses, a discovery that could have potential implications in the battle against obesity and diabetes. In a study published Monday, researchers at the University of Nottingham said that coffee may help stimulate our brown fat reserves, also known as brown adipose tissue, which play a key role in how quickly we can burn calories. There are two forms of fat cells, brown cells and white cells, and each plays a different role in our metabolism. While brown cells help generate heat, white cells are responsible for the storage of...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Coffee Source Type: news
CONCLUSIONS: The evidence included in this review indicates that effective, scalable interventions addressing SSB consumption at a population level exist. Implementation should be accompanied by high-quality evaluations using appropriate study designs, with a particular focus on the long-term effects of approaches suitable for large-scale implementation. PMID: 31194900 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
New Cochrane Review assesses evidence on different ways to reduce consumption of sugary drinksConsumption of sugary drinks is considered to be a key driver behind the global obesity epidemic, and is linked with tooth decay, diabetes and heart disease. Many public health bodies including the World Health Organization (WHO) have called upon governments, the food and drink industry, educational institutions, places of work and civil society to support healthier beverage choices. Thisnew Cochrane Review summarizes evidence from research studies testing different ways of reducing consumption of sugary drinks at a population lev...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
Conclusion: Using a largely theoretical model, the six modifiable lifestyle factors were estimated to be attributable to 50.9% of dementia cases in Barbados. Since the risk factors have much in common, any intervention that targets one of them could significantly reduce future dementia prevalence. PMID: 31093046 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Hongfei Gu1†, Shuang Shao2†, Jie Liu3,4,5, Zhenqian Fan2, Yu Chen2, Jingxian Ni3,4,5, Conglin Wang6, Jun Tu3,4,5, Xianjia Ning3,4,5, Yongzhong Lou1*, Bin Li1* and Jinghua Wang3,4,5* 1Department of Neurology, Tianjin Haibin People's Hospital, Tianjin, China 2Department of Endocrinology and Metabolism, The Second Hospital of Tianjin Medical University, Tianjin, China 3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China 4Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, China 5Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Cheng Luo1†, Xiqing Bian1†, Qian Zhang2, Zhenyan Xia1, Bowen Liu1, Qi Chen1, Chienchih Ke3,4, Jian-Lin Wu1* and Yonghua Zhao5* 1State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China 2Department of Biotherapy, Shenzhen Luohu People’s Hospital, Shenzhen, China 3Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan 4Biomedical Imaging Research Center, National Yang-Ming University, Taipei, Taiwan 5State Key Laboratory of Quality Research in Chinese Medi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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