First evidence of immune response targeting brain cells in autism

Dr. Matt AndersonIn a paper published in Annals of Neurology, Harvard neuropathologist Matthew Anderson, MD, PhD, and colleagues, report the presence of cellular features consistent with an immune response targeting specialized brain cells in more than two-thirds of autistic brains analyzed postmortem.These cellular characteristics —not previously observed in autism—lend critical new insight into autism’s origins and could pave the way to improved diagnosis and treatment for people with this disorder.Read morehere.
Source: neuropathology blog - Category: Radiology Tags: neuropathologists Source Type: blogs

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Publication date: Available online 5 December 2019Source: Brain, Behavior, and ImmunityAuthor(s): Alexandra Ramirez-Celis, Elizabeth Edmiston, Joseph Schauer, Tam Vu, Judy Van de WaterAbstractAutism spectrum disorder (ASD) is an important health issue and affects 1 in 59 children in the US. Prior studies determined that maternal autoantibody related (MAR) autism is thought to be associated with ∼23% of ASD cases. We previously identified seven MAR-specific autoantigens including CRMP1, CRMP2, GDA, LDHA, LDHB, STIP1, and YBX1. We subsequently described the epitope peptide sequences recognized by maternal autoantibodies ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 5 December 2019Source: NeuronAuthor(s): Sehyoun Yoon, Euan Parnell, Maria Kasherman, Marc P. Forrest, Kristoffer Myczek, Susitha Premarathne, Michelle C. Sanchez Vega, Michael Piper, Thomas H.J. Burne, Lachlan A. Jolly, Stephen A. Wood, Peter PenzesSummaryVariants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder. However, no upstream regulators of ankyrin-G at synapses are known. Here, we show that ankyrin-G interacts with Usp9X, a neurodevelopmental-disorder-assoc...
Source: Neuron - Category: Neuroscience Source Type: research
We examined whole-brain brain functional correlations (FC) and behavioral regulation through connectome predictive modelling (CPM). CPM is a data-driven protocol for developing predictive models of brain–behavior relationships and assessing their potential as ‘neuromarkers’ using cross-validation. The data stems from the ABIDE II and comprises 276 children with and without ASD (8-13 years).We identified networks whose FC predicted individual differences in behavioral regulation. These network models predicted novel individuals’ inhibition and shifting from FC data in both a leave-one-out, and split ...
Source: Developmental Cognitive Neuroscience - Category: Neuroscience Source Type: research
The objective of this study was to compare the reported frequency of physical activity and covariates in a large sample of children with ASD with children of similar age from the general population. The sample with ASD was derived from the Autism Treatment Network Registry Call Back Assessment (n = 611), and the general population data were derived from the National Survey of Children’s Health (NSCH) (n = 71,811). In addition, demographic, child, and family (parent) factors were examined in relation to frequency of recent physical activity in children with ASD. Among males in the 6−11 year-old age group, those ...
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Authors: Washington P, Paskov KM, Kalantarian H, Stockham N, Voss C, Kline A, Patnaik R, Chrisman B, Varma M, Tariq Q, Dunlap K, Schwartz J, Haber N, Wall DP Abstract Autism Spectrum Disorder (ASD) is a complex neuropsychiatric condition with a highly heterogeneous phenotype. Following the work of Duda et al., which uses a reduced feature set from the Social Responsiveness Scale, Second Edition (SRS) to distinguish ASD from ADHD, we performed item-level question selection on answers to the SRS to determine whether ASD can be distinguished from non-ASD using a similarly small subset of questions. To explore feature ...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
Abstract Animal-assisted therapy (AAT) has been suggested to increase prosocial behavior in children diagnosed with Autism Spectrum Disorder (ASD). Out of all the animals used in AAT, dogs have been found to be the most utilized and accessible. This systematic review examines the current state of literatur e on canine-assisted therapy (CAT) for children with ASD based on peer-reviewed articles. Five studies met inclusion and exclusion criteria. All articles found that presence of a therapy dog was correlated with increased frequency and duration of social behavior both throughout treatment and, in the case of one stud...
Source: Review Journal of Autism and Developmental Disorders - Category: Child Development Source Type: research
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Conclusions and implicationsAdjustments are needed to the custody process and environment to support interactions between autistic individuals and officers and improve the overall wellbeing of autistic individuals.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Conclusions: The TRANSITION-programme is a promising concept that deserves further evaluation. PMID: 31790309 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
(Northwestern University) Scientists have discovered why a specific genetic mutation causes intellectual disability and autism spectrum disorder in children. The mutation results in fewer brain synapses, making it harder for the brain to learn. The discovery offers a new target for treatment.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
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