The interpretation of post-neoadjuvant changes in non-neoplastic breast parenchyma: a case report

Neoadjuvant chemotherapy is the standard of care for many women with early breast cancer, depending on the cancer's hormonal and genomic profile. Post-chemotherapy breast specimens are frequently encountered by the breast pathologist and present an interesting challenge in terms of specimen processing and reporting. We briefly review the literature on current recommendations for processing breast cancer specimens following neoadjuvant chemotherapy and present a case that emphasises the care needed in recognising reactive chemotherapy-related changes in non-neoplastic breast parenchyma to avoid over-diagnosing residual malignancy.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: Short case Source Type: research