Digital Design of a Universal Rat Intraoral Device for Therapeutic Evaluation of a Topical Formulation against Candida-Associated Denture Stomatitis [Fungal and Parasitic Infections]

In this study, we aimed to evaluate the applicability of the novel formulation for the prevention of C. albicans colonization on denture material and development of clinical disease. To that end, using the latest technological advances in dental digital design and three-dimensional (3D) printing, we fabricated an intraoral device for rats with universal fit. The device was successfully installed and used to develop clinical DS. Importantly, by taking a preventative therapeutic approach, we demonstrated the potential clinical utility of the novel formulation as a safe and feasible prophylactic agent against DS.

Source: Infection and Immunity - November 17, 2019 Category: Infectious Diseases Authors: Sultan, A. S., Rizk, A. M., Vila, T., Ji, Y., Masri, R., Jabra-Rizk, M. A. Tags: Fungal and Parasitic Infections Source Type: research