Mass Spectrometric Analysis of L-carnitine and Its Esters: Potential Biomarkers of Disturbances in Carnitine Homeostasis.

CONCLUSION: The growing number of publications using mass spectrometry as a tool to investigate normal physiological conditions or reveal potential biomarkers of primary and secondary carnitine deficiencies shows that this tool brought a new perspective to carnitine research. PMID: 31729298 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Tags: Curr Mol Med Source Type: research

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CONCLUSION: Thus, diabetes mellitus itself was not an independent factor associated with IAD. A larger IAD was preferentially associated with the presence of PAD, and this association was modified by age. PMID: 31813900 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Publication date: Available online 10 December 2019Source: Canadian Journal of DiabetesAuthor(s): Antoine B.M. Clarke, Hanaa Ahsan, Jennifer Harrington, Farid H. MahmudAbstractBackgroundThe factors associated with allied healthcare professional (HCP) time spent face-to-face with patients in clinic have not been well described in type 1 diabetes (T1D) given the introduction of resource-intensive technologies and gaps in socioeconomic circumstances.ObjectiveTo evaluate clinical and social factors associated with non-physician HCP time in a pediatric T1D practice.MethodsNon-physician HCP workload data, including time spent in...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: Available online 25 September 2019Source: Canadian Journal of DiabetesAuthor(s): Tyler B. Dubois, Scot H. Simpson, Dean T. EurichAbstractObjectivesOur aim in this study was to determine whether differences exist in time to treatment intensification in newly treated type 2 diabetes patients in Canada and the United States (US).MethodsTwo separate retrospective cohorts of diabetes patients were used from Canada and the US. Time to treatment intensification (i.e. addition of a second antihyperglycemic agent after initial metformin use) was determined using multivariate Cox proportional hazard models.ResultsA...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
DiabetesMine interviews David Walton, new CEO of the influential nonprofit diabetes research org T1D Exchange.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
Authors: Suzuki S, Yokoyama A, Noro E, Aoki S, Shimizu K, Shimada H, Sugawara A Abstract Carbohydrate response element binding protein (ChREBP), a glucose responsive transcription factor, mainly regulates expression of genes involved in glucose metabolism and lipogenesis. Recently, ChREBP is speculated to be involved in the onset and progression of diabetic nephropathy (DN). However, there exists no report regarding the localization and function of ChREBP in the kidney. Therefore, we analyzed the localization of Chrebp mRNA expression in the wild type (WT) mice kidney using laser microdissection method, and observe...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Dental SciencesAuthor(s): Chih-Wei Tseng, Kuo-Ching Lu, Chun-Jen Huang
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
Publication date: Available online 5 November 2019Source: Indian Heart JournalAuthor(s): Sreenivas Reddy, Suraj Kumar, Jeet Ram Kashyap, Raghavendra Rao, Vikas Kadiyala, Hithesh Reddy, Naindeep Kaur, Vadivelu Ramalingam, Jaspreet KaurAbstractObjectiveThe coronary artery dimensions have important diagnostic and therapeutic implications in management of coronary artery disease (CAD). There is paucity of data on the coronary artery size in the Indian population as measured by intravascular ultrasound (IVUS).MethodsA total of 303 patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) wi...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Two experts debate whether women with diabetes are at greater overall risk for CVD than men, and if so, whether they need more aggressive risk factor management.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news
Publication date: Available online 10 December 2019Source: Progress in Natural Science: Materials InternationalAuthor(s): Kaifeng Chen, Shan Jiang, Yun Hong, Zibiao Li, Yun-Long Wu, Caisheng WuAbstractCRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/clustered regularly interspaced short palindromic repeat associated proteins 9) gene editing platform is a promising therapeutic tool for genetic disorders, due to its ability to manipulate the pathogenic gene in genomic level and to easily target specific gene by manipulating single-guide RNA. However, its successful delivery remains a challenge. Up to now...
Source: Progress in Natural Science: Materials International - Category: Materials Science Source Type: research
Publication date: Available online 9 December 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Tong Sun, Xiao HanAbstractDiabetes Mellitus is currently affecting more than 425 million people worldwide, among which over 90 % of the cases belong to type 2 diabetes. The number is growing quickly every year. Together with its many complications, the disease is causing tremendous social and economic burden and is classified as one of the leading causes of high morbidity and mortality rate. Residing in the islets of Langerhans, pancreatic beta cell serves as a central mediator in glucose homeostasis through secr...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
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