Flowers of Clerodendrum volubile modulates redox homeostasis and suppresses DNA fragmentation in Fe 2+  − induced oxidative hepatic and pancreatic injuries; and inhibits carbohydrate catabolic enzymes linked to type 2 diabetes

AbstractIntroductionMedicinal plants have long been recognized for their roles in the treatment and management of diabetes and its complications. The antioxidative and antidiabetic properties ofClerodendrum volubile flowers were investigated in vitro and ex vivo.MethodsThe flowers were sequentially extracted with solvents of increasing polarity (n-hexane, ethyl acetate, ethanol and water). The concentrated extracts were subjected to in vitro antioxidant assays using the 2,2 ′-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Ferric reducing antioxidant power (FRAP) protocols. Their inhibitory activities were investigated on α-glucosidase, pancreatic lipases, pancreatic ATPase and glucose-6-phosphatase activities. Their anti-oxidative and anti-apoptotic effects on Fe2+-induced oxidative injuries were also investigated in pancreatic and hepatic tissues ex vivo.ResultsThe extracts showed potent free radical scavenging activity and significantly (p 
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research

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Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
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Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
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Source: Cell Reports - Category: Cytology Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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