Flowers of Clerodendrum volubile modulates redox homeostasis and suppresses DNA fragmentation in Fe 2+ − induced oxidative hepatic and pancreatic injuries; and inhibits carbohydrate catabolic enzymes linked to type 2 diabetes
AbstractIntroductionMedicinal plants have long been recognized for their roles in the treatment and management of diabetes and its complications. The antioxidative and antidiabetic properties ofClerodendrum volubile flowers were investigated in vitro and ex vivo.MethodsThe flowers were sequentially extracted with solvents of increasing polarity (n-hexane, ethyl acetate, ethanol and water). The concentrated extracts were subjected to in vitro antioxidant assays using the 2,2 ′-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Ferric reducing antioxidant power (FRAP) protocols. Their inhibitory activities were investigated on α-glucosidase, pancreatic lipases, pancreatic ATPase and glucose-6-phosphatase activities. Their anti-oxidative and anti-apoptotic effects on Fe2+-induced oxidative injuries were also investigated in pancreatic and hepatic tissues ex vivo.ResultsThe extracts showed potent free radical scavenging activity and significantly (p
This article aims to discuss the consensus of the expert group on the role of AGP in T2DM patients on OADs and also reviews the various aspects of AGP and its interpretation; and the available evidences for disease management including treatment options based on AGP report. PMID: 31793278 [PubMed - in process]
Conclusion: CER evidence appeared to be associated with prescribing trends in GLP-1 agonists market; however, no associations were found in DPP4 inhibitors market. The translation of evidence into practice can be limited by the availability of superiority trials and timing of their availability. PMID: 31789054 [PubMed - as supplied by publisher]
Authors: Hostalek U, Zilahi Z Abstract Objectives: Prediabetes is characterised by elevation of indices of blood glucose that is insufficient to provoke a diagnosis of type 2 diabetes, but markedly increases the risk of developing type 2 diabetes in the future. Lifestyle interventions are the main therapeutic intervention for the management of prediabetes. Current guidelines also support treatment of prediabetes with metformin for selected subgroups of patients, and metformin has a therapeutic indication for this use in a number of countries.Methods: We performed an observational, non-interventional study of the ef...
The Pharmacogenomics Journal, Published online: 05 December 2019; doi:10.1038/s41397-019-0125-xStatin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study
Publication date: 3 December 2019Source: Cell Reports, Volume 29, Issue 10Author(s): Benjamin D. Stein, Diego Calzolari, Kristina Hellberg, Ying S. Hu, Lin He, Chien-Min Hung, Erin Q. Toyama, Debbie S. Ross, Björn F. Lillemeier, Lewis C. Cantley, John R. Yates, Reuben J. ShawSummaryMetformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited number of specific biochemical pathways studi...
CONCLUSIONS: Successful stem cell therapy in chronic liver cell failure patients can improve but not cure the associating type 2 diabetes by improving insulin resistance. PMID: 31789137 [PubMed - as supplied by publisher]
Condition: Diabetes Mellitus, Type 2 Intervention: Dietary Supplement: sucralose Sponsors: RenJi Hospital; ShiBei Hospital , JingAn District, Shanghai; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine; PuNan Hospital ,Shanghai Not yet recruiting
Discussion and conclusion: MDE possesses substantial antidiabetic activity, especially in lipid disorder regulation. This suggests that the use of MDE can be generalized to broader pharmacological studies, such as obesity and hyperlipidaemia. PMID: 31794270 [PubMed - in process]