Echocardiography improves prediction of major adverse cardiovascular events in a population with type 1 diabetes and without known heart disease: the Thousand & amp; 1 Study

AbstractAims/hypothesisCardiovascular disease is the most common comorbidity in type 1 diabetes. However, current guidelines do not include routine assessment of myocardial function. We investigated whether echocardiography provides incremental prognostic information in individuals with type 1 diabetes without known heart disease.MethodsA prospective cohort of individuals with type 1 diabetes without known heart disease was recruited from the outpatient clinic. Follow-up was performed through Danish national registers. The association of echocardiography with major adverse cardiovascular events (MACE) and the incremental prognostic value when added to the clinical Steno T1D Risk Engine were examined.ResultsA total of 1093 individuals were included: median (interquartile range) age 50.2 (39.2 –60.3) years and HbA1c 65 (56 –74) mmol/mol; 53% men; and mean (SD) BMI 25.5 (3.9) kg/m2 and diabetes duration 25.8 (14.6) years. During 7.5  years of follow-up, 145 (13.3%) experienced MACE. Echocardiography significantly and independently predicted MACE: left ventricular ejection fraction (LVEF)
Source: Diabetologia - Category: Endocrinology Source Type: research

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
WEDNESDAY, Nov. 20, 2019 -- People with inflammatory bowel disease, type 1 diabetes or blood clots may be at increased risk for rheumatoid arthritis -- and people with rheumatoid arthritis are at added risk for heart disease, blood clots and sleep...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conclusion: Meta-analyses of all glucose-lowering RCTs involving patients with diabetes provide precise estimates of benefits for CHD and major cardiovascular events after consideration of the resulting ongoing BP difference. No benefit or harm on mortality, heart failure and stroke were noticed, while discontinuations related to adverse events because of treatment were increased following glucose-lowering. The extent of glucose-lowering is proportionally related to changes of CHD and stroke composite, and treatment-related discontinuations.
Source: Journal of Hypertension - Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research
Abstract Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterised by a destruction of pancreatic  cells, which leads to absolute insulin deficiency. Persistently high glycaemia causes vascular damage throughout the body. Microvascular complications com-prise the following: nephropathy, retinopathy, and neuropathy. Macrovascular complications include coronary heart disease (CHD), which may result in myocardial infarction, cerebrovascular disease (leading to strokes), and peripheral vascular disease. The pathogene-sis of vascular complications is multifactorial and is probably the combination...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - Category: Endocrinology Authors: Tags: Pediatr Endocrinol Diabetes Metab Source Type: research
Women with type 1 or 2 diabetes have a greater risk of developing heart failure than men, according to research published in the journal of the European Association for the Study of Diabetes.Independent
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
The risk was particularly high for type 1 diabetics, according to a large study by the George Institute for Global Health in Oxford. Diabetes is already known to put patients at a higher risk of heart disease.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusions: VDD was highly prevalent in patients with T1D. There was no significant correlation between 25OHD levels and lipid profile in patients with T1D. VD supplementation for 4 months had a significant lowering effect on LDL and HbA1c.Horm Res Paediatr
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
Authors: Šuran D, Kanič V, Naji F, Krajnc I, Čokolič M, Zemljič E, Sinkovič A Abstract In patients with type 1 diabetes mellitus (T1DM) imaging studies have demonstrated an increased prevalence of left ventricular diastolic dysfunction and increased left ventricular mass (LVM) unrelated to arterial hypertension and ischemic heart disease. The aim of our study was to identify potential predictors of early subclinical changes in cardiac chamber size and function in such patients. Sixty-one middle-aged asymptomatic normotensive patients with T1DM were included in the study. Conventional and tissue Doppler ...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Anyone who remembers the days before finger stick blood glucose meters became available to people with diabetes will recall how awful life was for diabetics. All they had was urine dipsticks which were sloppy, yielded only crude non-quantitative feedback on blood sugars, and gave you a gauge of what blood sugars were in the recent past, not the present. It meant that dosing insulin or diabetes drugs was grotesquely imprecise and accounted for many episodes of hypoglycemic coma and acceleration of diabetic complications. It was not uncommon in those days, for instance, for a type 1 diabetic to be blind and experience kidney...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO bowel flora Inflammation probiotic undoctored wheat belly Source Type: blogs
The increasing global prevalence of diabetes has been accompanied by a rise in diabetes-related conditions. This includes diabetic cardiomyopathy, a progressive form of heart disease that occurs with both insulin-dependent (type-1) and insulin-independent (type-2) diabetes and arises in the absence of hypertension or coronary artery disease. Over time, diabetic cardiomyopathy can develop into overt heart failure. Like other forms of cardiomyopathy, diabetic cardiomyopathy is accompanied by alterations in metabolism which could lead to further progression of the pathology, with metabolic derangement postulated to precede fu...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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