Pharmacokinetic modeling of intravenous sildenafil in newborns with congenital diaphragmatic hernia

ConclusionsThis model for sildenafil in CDH patients shows that concentration-targeted sildenafil dosing of 0.4 mg/kg in 3 h, followed by 1.6 mg/kg/day continuous infusion achieves appropriate sildenafil plasma levels.

http://link.springer.com/10.1007/s00228-019-02767-1

Source: European Journal of Clinical Pharmacology - November 17, 2019 Category: Drugs & Pharmacology Source Type: research