Association of pemphigus and pemphigoid with osteoporosis and pathological fractures

AbstractPatients with pemphigus and bullous pemphigoid (BP) have potential risk factors for osteoporosis and/or fractures. To determine whether pemphigus and BP are associated with osteoporosis and fractures in the US, a  cross-sectional study of 198,102,435 adults was performed, including 4506 with pemphigus and 8864 with BP from the 2006–2012 National Emergency Department Sample, a 20% sample of emergency care visits throughout the US. Pemphigus was associated with higher odds (multivariate logistic regression ; adjusted odds ratio [95% confidence intervals]) of osteopenia (2.20 [1.59–3.05]), osteoporosis (2.54 [2.16–2.98]), osteomalacia (29.70 [4.05–217.83]), and pathological fractures (2.04 [1.42–2.91]). BP was associated with osteoporosis (1.55 [1.39–1.73]) and pathological fractures (1.52 [1 .22–1.88]). When compared to BP, pemphigus was associated with higher odds of osteopenia (1.59 [1.06–2.41]), osteoporosis (1.38 [1.18–1.63]), and fractures (1.26 [1.04–1.53]), particularly of the ulna and radius (3.17 [1.23–8.17]). Patients with pemphigus or BP as well as long-term systemi c corticosteroid use had highest odds of osteoporosis and fractures. No data were available on treatments for pemphigus or BP. Pemphigus and BP were associated with osteopenia, osteoporosis, and pathologic fractures. Patients with PEM and BP may benefit from increased screening for osteoporosis and interventions to prevent...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research

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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Background: Patients with pemphigus (PEM) and bullous pemphigoid (BP) have risk factors for decreased bone mineral density including long-term use of systemic corticosteroids and chronic inflammation. Few studies examined the associations of PEM and BP with osteoporosis and fractures. We sought to determine whether PEM and BP are associated with osteoporosis and fracture in the US population.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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