Development of novel therapeutics for glaucoma filtration surgery based on transforming growth factor- β receptor 1 inhibition

New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ05393J, PaperMaja Zivkovic, Marko Zlatanovic, Nevena Zlatanovic, Mladjan Golubovi ć, Aleksandar M Veselinović Belonging to the group of cytokines, transforming growth factor- β, is involved in numerous physiological processes with two of its main receptors/kinases - transforming growth factor-β receptor type 1 and 2.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research

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Conditions:   Cataract;   Age-related Cataract;   Circadian Rhythm Disorders;   Glaucoma;   Age Related Macular Degeneration Interventions:   Device: Blue-light filtering intraocular lens;   Device: Conventional intraocular lens Sponsor:   University of Pittsburgh Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Open Angle Glaucoma Interventions:   Biological: 2.5mg ANX007;   Biological: 5.0mg ANX007;   Other: Sham Procedure Sponsor:   Annexon, Inc. Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: We conclude that chronic topical timolol administration may aggravate a cardiac conduction defect leading to an AV block that is only temporarily resolved by timolol cessation. Patients taking timolol should be routinely monitored for cardiovascular aberrations and if any detected, immediately discontinue timolol therapy. Individuals experiencing timolol induced cardiovascular side effects should receive long term follow-up even if symptoms resolve, as they may be indicative of an underlying conduction defect. PMID: 31791399 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
XEN Gel Stent, REF 5513-001(US Model), Sterile, RX Only, (01)10888628032439 ; Other Model Numbers: 5507-001(Global Model) and 5517-001(Australia model) Implant for glaucoma treatment.
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
This study aims to evaluate the effectiveness and safety of double-session micropulse transscleral (MP3) laser for the treatment of glaucoma. This was a retrospective chart review of all patients who underwent MP3 laser with the standard protocol and were within at least 12  months of their follow-up appointments. Eyes were treated at 2000 mW with 31.3% duty cycle for 80 s per treatment session, with double sessions in each hemifield alternating between upper and lower and upper and lower. Success criterion was defined as a greater than 20% reduction in intraocular pressure (IOP) and an IOP between 6 and 18&...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
AbstractPurposeTo explore the relationships between the aqueous and vitreous levels of vascular endothelial growth factor-A (VEGF-A), interleukin-8 (IL-8), placental growth factor (PlGF) and erythropoietin (EPO) in proliferative diabetic retinopathy (PDR) and neovascular glaucoma (NVG).MethodsAqueous and vitreous samples were obtained from patients with PDR and NVG during surgery. Aqueous and vitreous concentrations of VEGF-A, IL-8, PlGF and EPO were measured via enzyme-linked immunosorbent assay.ResultsNo correlation between the aqueous and vitreous levels of VEGF-A, IL-8, PlGF or EPO was found in both the PDR and the NVG...
Source: International Ophthalmology - Category: Opthalmology Source Type: research
CAMBRIDGE (CBS) – A new treatment could help ease the passage of kidney stones, according to researchers at MIT and Massachusetts General Hospital. Scientists said this week that muscle relaxants can reduce the contractions that cause pain when passing the stones. About 1 in 10 people will have the painful experience of kidney stones. They cause more than 500,000 emergency room visits in the United States every year. But local researchers think they’ve made a discovery that can help. They say delivering a combination of two muscle relaxants directly to the ureter, the tube that connects the kidneys and bladder,...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston Syndicated Local Cambridge News Kidney Stones MIT Source Type: news
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print.
Source: Journal of Ocular Pharmacology and Therapeutics - Category: Opthalmology Source Type: research
TUESDAY, Dec. 3, 2019 -- Exposure to ambient air pollution is associated with a higher risk for glaucoma and adverse structural characteristics of the disease, according to a study published in the November issue of Investigative Ophthalmology&...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Glaucoma or glaucoma suspect may develop in the first year after pediatric lensectomy, and infants three months or younger and those with post-procedure aphakia are especially at risk, a multicenter registry study revealed.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Ophthalmology News Source Type: news
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