Two distinct tumorigenic processes in endometrial endometrioid adenocarcinoma.

Two distinct tumorigenic processes in endometrial endometrioid adenocarcinoma. Am J Pathol. 2019 Nov 13;: Authors: Sugiyama Y, Gotoh O, Fukui N, Tanaka N, Hasumi K, Takazawa Y, Noda T, Mori S Abstract Endometrial endometrioid adenocarcinoma (EEA) is conventionally considered to be a single pathological entity that develops through a hyperplasia-carcinoma sequence under the influence of estrogen. Previously, another EEA subtype was described and proposed to arise directly from normal endometrium. These conventional and de novo subtypes are designated groups 1 and 2, respectively. To identify the molecular mechanisms of these distinct tumorigenic processes, we conducted comprehensive integrated analyses of genomic data with hormonal status for group-1 paired carcinoma and hyperplasia and group-2 carcinoma samples. Whereas group-1 carcinomas mostly exhibited genomically stable characteristics and the activation of estrogen signaling, group-2 EEAs showed enriched hypermutator and CpG island methylator phenotypes. Pairwise comparisons of hyperplasia and carcinoma, along with time-course analyses of the hyperplasia-carcinoma sequence revealed the acquisition of driver mutations in the evolutionary process of hyperplasia but not in the transition from hyperplasia to carcinoma. The current study confirms the existence of two different histopathological programs during EEA development that harbor distinct molecular bases, and demonstrates the...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research