Using Multiparametric Magnetic Resonance Imaging to Shift Prostate Cancer Diagnosis Toward Clinically Significant Disease and Minimize Overdiagnosis (and Overtreatment)

Minimizing the overdiagnosis and overtreatment of localized prostate cancer is a huge challenge for both patients and health care systems. Evidence now supports the role of prebiopsy multiparametric magnetic resonance imaging (mp-MRI) as a triage tool.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Feature Source Type: research

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Prostate Cancer and Prostatic Diseases, Published online: 13 December 2019; doi:10.1038/s41391-019-0198-2Correction: Confirmatory multiparametric magnetic resonance imaging at recruitment confers prolonged stay in active surveillance and decreases the rate of upgrading at follow-up
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research
PMID: 31832747 [PubMed - as supplied by publisher]
Source: Der Urologe. Ausg. A - Category: Urology & Nephrology Authors: Tags: Urologe A Source Type: research
Abstract PURPOSE: This guideline provides recommendations for available tissue-based prostate cancer biomarkers geared toward patient selection for active surveillance, identification of clinically significant disease, choice of postprostatectomy adjuvant versus salvage radiotherapy, and to address emerging questions such as the relative value of tissue biomarkers compared with magnetic resonance imaging. METHODS: An ASCO multidisciplinary Expert Panel, with representatives from the European Association of Urology, American Urological Association, and the College of American Pathologists, conducted a systemat...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
Conclusion: By use of our nomogram, bone scans of men with prostate cancer can be avoided in a large proportion of men. PMID: 31805808 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Publication date: Available online 6 December 2019Source: European UrologyAuthor(s): Marloes van der Leest, Bas Israël, Rianne R.M. Engels, Jelle O. Barentsz
Source: European Urology - Category: Urology & Nephrology Source Type: research
This report describes the feasibility and short-term outcomes of an...
Source: BMC Urology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Abstract CLINICAL/METHODICAL ISSUE: In view of the diagnostic complexity and the large number of examinations, modern radiology is challenged to identify clinically significant prostate cancer (PCa) with high sensitivity and specificity. Meanwhile overdiagnosis and overtreatment of clinically nonsignificant carcinomas need to be avoided. STANDARD RADIOLOGICAL METHODS: Increasingly, international guidelines recommend multiparametric magnetic resonance imaging (mpMRI) as first-line investigation in patients with suspected PCa. METHODICAL INNOVATIONS: Image interpretation according to the PI-RADS criteria i...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Abstract OBJECTIVES: To estimate the impact of peri-prostatic fat (PPF) measurements using preoperative magnetic resonance imaging on the prediction of prostate cancer (PCa) with transrectal ultrasound-guided biopsy. PATIENTS AND METHODS: We performed a retrospective 2-center study on 660 consecutive patients receiving transrectal ultrasound-guided biopsy-biopsy from June 2016 to October 2018. Pathologic and immunohistochemical characteristics were collected. PPF measurements including PPF area (PPFA) and PPFA to prostate area (PA) ratio (PPFA/PA) were assessed by preoperative staging magnetic resonance imagi...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
ConclusionsmpMRI detected the majority of high-grade and large cancers, but had low sensitivity in the PZ, posterior, and apex and base of the gland. The high prevalence of low-volume, low-Gleason score index tumors, as well as satellite tumors in those areas, accounted for the difference.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
AbstractAccurate early detection of recurrent prostate cancer after surgical or nonsurgical treatment is increasingly relevant in the era of evolving options for salvage therapy. The importance of differentiating between local tumor recurrence, distant metastatic disease, and a combination of both in a patient with biochemical recurrence of prostate cancer is essential for appropriate treatment selection. Magnetic resonance imaging (MRI) is the best test for localization and characterization of locally residual or recurrent prostate cancer. It is essential for the radiologist involved in prostate MRI interpretation to be f...
Source: Abdominal Imaging - Category: Radiology Source Type: research
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