Imbalance in glycemic control between the treatment and placebo groups in cardiovascular outcome trials in type 2 diabetes

ConclusionsThe safety and efficacy of new hypoglycemic agents are potentially inflated because the participants in the placebo groups unexpectedly exhibited inferior glycemic control throughout the trial compared with the outcomes in the treatment groups. This imbalance may distort data interpretation and mask potential risks of the drugs. Re-analysis with adjustment for HbA1c concentrations would determine whether the results of these CVOTs were biased by the difference in glycemic control between the treatment and placebo groups and reveal potential effects of the test drugs independent of glycemic control.
Source: Journal of Pharmaceutical Policy and Practice - Category: Pharmaceuticals Source Type: research

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TYPE 2 diabetes is a chronic condition that requires a person to overhaul aspects of their lifestyle to keep rising blood sugar levels in check. Diet plays a decisive role in regulating blood sugar and warding off the threat of developing serious conditions and evidence is increasingly singling out certain items for their blood sugar-lowering benefits, including a certain fruit.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Patients with Type 2 Diabetes Mellitus (T2DM) suffer from a higher incidence and severity of pulmonary infections. This is likely due to immune impairment and structural abnormalities caused by T2DM-induced oxidative stress (OS) and chronic inflammation. Modulation of the Renin Angiotensin System (RAS) through blockade of the actions of angiotensin II (AII), or inducing the protective pathway, has the potential to reduce these pathological pathways. The effects of Angiotensin 1–7 [A(1-7)] and NorLeu3-A(1-7) [NorLeu], ligands of the protective RAS, on the innate immune response were evaluated in the db/db mouse model ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS Silicone oil endotamponade in PPV was associated with an increased risk of IOP at 24-month follow-up. PMID: 31811816 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Functional FoodsAuthor(s): Milkica Grabež, Ranko Škrbić, Miloš P. Stojiljković, Vesna Rudić-Grujić, Marija Paunović, Aleksandra Arsić, Snježana Petrović, Vesna Vučić, Bosa Mirjanić-Azarić, Katarina Šavikin, Nebojša Menković, Teodora Janković, Nađa VasiljevićAbstractPomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
ConclusionsThe use of the tesaglitazar-[F7, P34]-NPY conjugate is a promising strategy to apply the beneficial PPARα/γ effects in adipocytes while potentially omitting adverse effects in other tissues.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 9 December 2019Source: Canadian Journal of DiabetesAuthor(s): Lingning Huang, Yongze Zhang, Yunmin Wang, Ximei Shen, Sunjie YanAbstractAimsInvestigate association between diabetic peripheral neuropathy (DPN)and above normal blood pressure in non-hypertensive patients with type 2 diabetes mellitus(T2DM). Compare the achievement of clinical target for DPN and non-DPN withT2DM .MethodsA retrospective survey was administered to 3810 patients with type 2 diabetes. Cases were grouped according to the Toronto Clinical Scoring System (TCSS): Non-DPN, Mild DPN, Moderate DPN and Severe DPN. 1835 pa...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
In this study, extracts of Trapa natans pericarp were tested both in vitro and in vivo through a high-fat diet with a single medium dosage streptozotocin injection induced type 2 diabetic mice. Different solvent extracts of Trapa natans pericarp showed α -amylase and α -glucosidase inhibitory activity. After four weeks administration, the ethyl acetate extract of Trapa natans pericarp (50 and 100 mg/kg b.w.) reduced fasting blood glucose level, ameliorated oral glucose tolerance and insulin resistance, improved serum lipids alterations in type 2 diabetic mice as well. Additionally, ethyl acetate extract signifi...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Condition:   Diabetes Mellitus, Type 2 Interventions:   Dietary Supplement: BPL-1 Probiotic capsules;   Dietary Supplement: Placebo Sponsor:   Mónica Marazuela Azpíroz Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Type 2 Diabetes;   Gestational Diabetes Intervention:   Other: Observational Sponsors:   Universiti Putra Malaysia;   Ministry of Health, Malaysia;   Universiti Teknologi Mara Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
According to a study published inDiabetologia, preterm birth may increase risk of developing type 1 and type 2 diabetes in adulthood.Med Page Today
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
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