Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia – An Asthma Mimicker
A 74-year-old woman with a prior history of tobacco use presented with a chronic cough productive of clear sputum. She carried a diagnosis of asthma for the past 20 years but had minimal improvement in symptoms despite treatment with inhaled corticosteroids and long acting beta agonists. Her medical history was remarkable for gastroesophageal reflux disease that resolved after an esophageal fundoplication.
Conclusions: CC causes other than asthma, UACS and GER are not rare in non-smoking adults and should be considered in the differential diagnosis of CC.
Conclusions: During IMP/pH monitoring patients with CVA did not record more cough episodes at night than other patients. Perception of cough episodes at night was more common in patients with GER-related cough than in patients without GER.
Conclusions: Large proportions of chronic cough patients in this trial were diagnosed with GERD, asthma, or allergic rhinitis. Despite receiving treatment for these conditions, chronic cough for these subjects had persisted for over a decade.
Conclusions: with the exception of a later onset and higher BMI in patients with CVA, the clinical features of asthma in patients with CVA and CPA are comparable.
Conclusions: Studies have demonstrated that an increase in airway temperature can activate and sensitize some transient receptor potential vanilloid (TRPV) expressed by sensory neurons; activation of these C-fiber afferents can elicit cough. Our data demonstrate that EBT is elevated in children with chronic cough. The role of EBT in chronic cough needs further investigation.
This study demonstrates the difficulties which arise when assigning a diagnosis of asthma to a symptomatic patient. We believe that careful assessment of airway physiology should be a cornerstone of the diagnostic process in the case of this disease.
In conclusion, the incidence of M abscessus does not seem to be increasing in non-CF patients in our institution. There may be an epidemiological link with acid suppression and reflux disease, this hypothesis has been previously reported in patients with CF.
Conclusions: The prevalence of CC was lower than reported in previous studies. People with possible CC had higher rates of underlying conditions associated with CC. These observations may suggest poor recognition and/or under-recording of CC in primary care. PMID: 31558053 [PubMed - as supplied by publisher]
This study aimed to investigate the changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China, and to explore the clinical significance. Methods: Medical records of 1,311 patients with chronic cough who visit our hospital between January 2009 and December 2016 were retrospectively reviewed. The etiologies of chronic cough were identified according to a standardized step-by-step diagnostic protocol and the changes in the etiological frequency of chronic cough over the years were using the Chi-squared (χ2) test. Results: Cough variant asthma (CVA) (449/1,311, 34.2%), gastroesophage...
CONCLUSIONS: NAEB, CVA, and UACS are common causes of chronic cough in patients with AR. FeNO can first be used to discriminate patients with CVA/NAEB, then FEF25-75 (or combined with FeNO) can further discriminate patients with CVA from those with CVA/NAEB. PMID: 31552718 [PubMed]