A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication
Conclusions: Solithromycin concentrations in DBS were similar to those measured in LPS and did not require correction for hematocrit or protein binding.
Publication date: Available online 4 December 2019Source: Joint Bone SpineAuthor(s): Chang-Fu Kuo, Patricia B. Burns, Jung-Sheng Chen, Lu Wang, Kevin C. ChungAbstractObjective: The purpose of the study is to investigate the risk of preventable hospitalization among patients with rheumatoid arthritis (RA).Methods: We identified 11,852 incident RA patients and 59,260 age-, sex-, and index year-matched controls from the Taiwan National Health Insurance Database. Index date was the RA diagnosis date for cases, which was assigned to their matched controls. The odds ratios (OR) of preventable hospitalizations between RA patients...
Bacterial pneumonia is a common clinical diagnosis in dogs but seems to occur less often in cats. Underlying causes include viral infection, aspiration injury, foreign body inhalation, and defects in clearance of respiratory secretions. Identification of the specific organisms involved in disease, appropriate use of antibiotics and adjunct therapy, and control of risk factors for pneumonia improve management.
In conclusion, antibiotic therapy was often incomplete, was generally guideline discordant, exhibited limited diversity of selection, and frequently lacked diagnostic confirmation. These data, combined with local susceptibility patterns, may be used to foster AMS efforts for improved compliance with guidelines at MZRH in the future. PMID: 31802729 [PubMed - as supplied by publisher]
Conclusions. BLT appears to be associated with better long-term survival, better postoperative lung function, and less BOS compared with SLT. In-hospital mortality and postoperative complications (except BOS) were similar between the 2 groups.
PMID: 31764045 [PubMed - in process]
AbstractOmadacycline is a novel aminomethylcycline antibiotic (antibacterial). Omadacycline has had chemical structure modifications at the C9 and C7 positions of the core tetracycline rings that allow stability in the efflux pump and ribosomal protection protein mechanisms of tetracycline resistance. The systemic exposure (i.e., maximum plasma concentrations [Cmax] and area under the plasma concentration –time curve [AUC]) after intravenous (IV) administration were linear and predictable over the dose range of 25 and 600 mg in healthy subjects. The oral bioavailability of omadacycline was 34.5% under fasted con...
Abstract Cell death is increasingly recognized as a driving factor in the development of acute lung injury. Necroptosis, an immunogenic regulated cell death program important in innate immunity, has been implicated in the development of lung injury in a diverse range of conditions. Characterized by lytic cell death and consequent extracellular release of endogenous inflammatory mediators, necroptosis can be both beneficial and deleterious to the host depending on the context. Here, we review recent investigations linking necroptosis and the development of experimental lung injury. We assess the consequences of nec...
This article reviewed the limited literature regarding C. pneumoniae and immunosuppressed cancer patients, concluding that prompt diagnosis and standard recommended treatment of C. pneumoniae will provide favorable outcomes.
Lefamulin (Xenleta) is a new antibiotic approved to treat adults with community-acquired bacterial pneumonia.Lefamulin's labeling warns of the risk of QT interval prolongation, the potential for fetal harm, and the risk of Clostridium difficile–associated diarrhea.
Conclusions: An imbalance in the oral bacterial flora could be a risk factor for AE-IPF.