MiR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1 β pathway

Myocardial infarction (MI) is the most common cause of cardiovascular morbidity and mortality worldwide. Despite the identification of many pathogenic genes associated with MI, the underlying molecular mechanisms remain poorly understood. MicroRNAs (miRNAs, miRs), which regulate target genes at the post-transcriptional level, play a significant role in the regulation of cardiovascular diseases such as MI. Pyroptosis is a caspase-1-dependent pro-inflammatory programmed cell death (PCD) mechanism.

Source: International Journal of Cardiology - November 16, 2019 Category: Cardiology Authors: Anqi Li, Xueying Ding, Yahan Yu, Ying Qin, Yanan Jiang, Xi Chen, Er Yue, Syeda M. Zahra, Xi Sun, Xinyao Wang, Yan Yan, Long Ren, Shuo Wang, Lu Chai, Baofeng Yang, Yunlong Bai Source Type: research