Association of the HSD11B1rs12086634(T/G) gene polymorphism and IL6 serum level with the risk of polycystic ovary syndrome

In this study, serum IL6 was measured by ELISA, and the HSD11B1rs12086634(T/G) polymorphism was analyzed using a TaqMan allelic discrimination assay technique. There were statistically significant differences between the two studied groups concerning the serum IL-6 level and HSD11B1rs12086634(T/G) genotype distribution, with increased serum IL6 and increased frequencies of the GG and TG genotypes in patients with PCO. The GG genotype of HSD11B1 rs12086634(T/G) and its associated high level of serum IL-6 may represent genetic risk factors for PCOS.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research

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Publication date: Available online 2 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Valentina Guarnotta, Marcello Niceta, Marianna Bono, Serena Marchese, Carmelo Fabiano, Serena Indelicato, Francesca Di Gaudio, Piernicola Garofalo, Carla GiordanoAbstractNon-classical congenital adrenal hyperplasia (NC-CAH) includes a group of genetic disorders due to a broad class of CYP21A2 variants identifying a disease-causing ‘C’ genotype.The heterozygous carriers of CYP21 mutations are at increased risk of developing clinically evident hyperandrogenism, even though clinical and lab...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Genes and environment Source Type: research
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Source: Thrombosis Research - Category: Hematology Authors: Tags: Full Length Article Source Type: research
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
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Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
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