Teens with heart disease improve exercise capacity in large clinical trial

(Children's Hospital of Philadelphia) The largest-ever clinical trial of a medication for pediatric cardiology patients found that an oral drug significantly improved exercise capacity in adolescent patients with severe, congenital single-ventricle heart defects. A study leader says the physiologic benefits represent a milestone in the care of those who have undergone the Fontan procedure, a palliative operation for single-ventricle disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: December 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 12Author(s): Marie-A. Chaix, Michael A. Gatzoulis, Gerhard-Paul Diller, Paul Khairy, Erwin N. OechslinAbstractEisenmenger syndrome is the most severe and extreme phenotype of pulmonary arterial hypertension associated with congenital heart disease. A large nonrestrictive systemic left-to-right shunt triggers the development of pulmonary vascular disease, progressive pulmonary arterial hypertension, and increasing pulmonary vascular resistance at the systemic level, which ultimately results in shunt reversal. Herein, we review the changi...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Conclusion: Five-year survival is higher in the I group (p>0.05). But mortality from cancer recurrence is lower in the II group (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
ConclusionsAreas of interest include myocardiocyte regeneration, tissue graft development to minimize reoperations, and methods of stem cell delivery. While several small trials are showing promise, it is too soon to make definitive statements about the future of stem cell therapies in this field.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: REVIEW ARTICLE Source Type: research
This study sought to compare the outcomes and costs of elective and emergent invasive cardiac procedures for interstage patients. Retrospective review of discharge data from The Vizient Clinical Data Base/Resource Manager ™, a national health care analytics platform. The database was queried for admissions from 10/2014 to 12/2017 for children 1–6 months old with ICD-9 or ICD-10 codes for SV CHD who underwent invasive cardiac procedures. Demographics, length of stay (LOS), complication rate, in-hospital mortality and direct costs were compared between elective and emergent admissions usingt test or χ2, ...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 10 October 2019Source: Canadian Journal of CardiologyAuthor(s): Marie-A. Chaix, Michael A. Gatzoulis, Gerhard-Paul Diller, Paul Khairy, Erwin N. OechslinAbstractEisenmenger syndrome is the most severe and extreme phenotype of pulmonary arterial hypertension associated with congenital heart disease. A large non-restrictive systemic left-to-right shunt triggers the development of pulmonary vascular disease, progressive pulmonary arterial hypertension and increasing pulmonary vascular resistance at the systemic level, which ultimately results in shunt reversal. Herein, we review the changing...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
CONCLUSIONS: While a majority of pediatric cardiothoracic surgeons are familiar with palliative care, there is variation in perception of appropriate timing of consultation. Significant barriers to consultation still exist, including concern that parents will think they are "giving" up, undermining parental hope, and influence of palliative care on the medical care team's approach. PMID: 31597507 [PubMed - as supplied by publisher]
Source: Journal of Palliative Care - Category: Palliative Care Tags: J Palliat Care Source Type: research
Purpose of review Advanced heart failure in children is characterized by dynamic clinical trajectories, uncertainty of prognosis, and intermittent need for difficult decision-making, often related to novel therapeutic interventions with uncertain impact on quality of life. This review will examine the current role of palliative care to support this unique population. Recent findings Pediatric heart failure patients commonly die in ICUs with high burden of invasive therapies together with end of life care needs. In addition, several studies advocate for integration of palliative care early in disease trajectory, not on...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: CARDIOVASCULAR MEDICINE: Edited by Daniel Bernstein Source Type: research
Journal of Perinatology, Published online: 05 September 2019; doi:10.1038/s41372-019-0490-yEarly palliative care reduces stress in parents of neonates with congenital heart disease: validation of the “Baby, Attachment, Comfort Interventions”
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
Little is known about advance care planning (ACP) and palliative care needs among adults with congenital heart disease (ACHD).
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Little is known about advance care planning (ACP) and palliative care needs among adults with congenital heart disease (ACHD).
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Tags: Special Series: Science in Action: Evidence and Opportunities for Palliative Care Across Diverse Populations and Care Settings Source Type: research
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