Intimal sarcoma of the left atrium presenting with transient ischaemic attack — A case report and review of the literature

Publication date: Available online 16 November 2019Source: Journal of Cardiology CasesAuthor(s): Lucy Grant, Ian Morgan, VaiyaPuri Sumathi, Nabeel SalmonsAbstractA 31-year-old female with a history of polycystic ovary syndrome and two recent miscarriages presented with symptoms of a transient ischemic attack. Echocardiography to assess for possible embolic source identified a 4.8 cm left atrial mass, presumed to be an atrial myxoma.At surgery the tumor was suspicious of malignancy. Histopathology revealed a heterogeneous hyper- and hypo-cellular spindle cell tumor showing mild atypia. Atrial myxoma markers were negative. The Ki67 proliferation factor was 30% and fluorescence in situ hybridization (FISH) analysis showed MDM2 amplification. Expert review confirmed the morphological, immunohistochemical, and FISH features to be of a cardiac intimal sarcoma.Recent improvements in imaging, surgery, and molecular testing have increased diagnoses of primary cardiac intimal sarcomas. Here we discuss the pathological and clinical implications of these rare atrial myxoma mimics.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research

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In this study, a fluorescence biosensor based on the peroxidase mimicking activity of platinum nanoparticles (Pt NPs) was fabricated for rapid detection of hypoxanthine (Hx), which is a sensitive indicator of the freshness of aquatic products. The fluorescence intensity of the sensing system had a linear relationship with the concentration of Hx in the range of 8–2500 μM, and the limit of detection was as low as 2.88 μM (S/N = 3). Moreover, benefiting from the excellent selectivity of the biosensor, Hx content in fish, shrimp and squid samples could be quickly detected with good recovery rat...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 11 December 2019Source: The Veterinary JournalAuthor(s): M.J. Hezzell, J.D. Foster, M.A. Oyama, J. Buch, G. Farace, J.J. Quinn, M. YerramilliAbstractPathophysiological cardiac and renal interactions are termed cardiovascular-renal disorder (CvRD). Cardiovascular disease/dysfunction secondary to kidney disease (CvRDK), is a leading cause of death in human chronic kidney disease (CKD) patients. The presence and clinical impact of CvRDK in dogs with CKD is unknown. We hypothesized that echocardiographic measurements, and cardiac and renal biomarkers, will be altered in dogs with CKD and asso...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Authors: Ducloyer JB, Ducloyer M, Tessoulin B, Lebranchu P, Deltour JB PMID: 31813551 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Publication date: Available online 11 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Saekil Yun, Seung-Jun Lee, Sib Sankar Giri, Hyoun Joong Kim, Sang Geun Kim, Sang Wha Kim, Se Jin Han, Jun Kwon, Woo Taek Oh, Se Chang ParkAbstractThe aim of this study was to develop and evaluate a novel route of administration for vaccinating fish against Aeromonas hydrophila infection using a dissolving microneedles (MNs) patch. The A. hydrophila JUNAH strain was inactivated with formalin and used as a vaccine antigen. It was mixed with dissolvable carboxymethyl cellulose (CMC) as the matrix material to produce the MNs pat...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
We reported higher values of hematocrit, hemoglobin, Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Volume (MCV), White Blood Cell (WBC), Red Blood Cell (RBC) and lymphocytes for treated groups. Innate immune responses (Alternative complement activity (ACH50) in M2 and M3 group, total Immunoglobulin (Ig) and lysozyme in M3), mucosal immune parameters (ACH50, total Ig for M2 and M3 group and lysozyme in all treated groups) were enhanced. Activities of digestive enzymes (protease in all treated groups, amylase for 3 and 5%, while lipase only for 5%) and lower activity of liver ALT enzyme in individuals treated with high...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 10 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): HamidrezaAhmadniaye Motlagh, Omid Safari, Yahya Selahvarzi, Ali Baghalian, Elham KiaAbstractIn the present study, the effect of aqueous garlic (Allium sativum) extract on skin mucus immune parameters of Poecilia reticulata was evaluated. A total of 240 P. reticulate juveniles, weighing 0.013 ± 0.001 g, were randomly stocked in 12 experimental glass tanks at a density of 30 fish per tank. The fish were fed with diets supplemented with garlic extract at the concentrations of 0, 0.10, 0.15, and 0.20 ml kg&minus...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 10 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Peng Fei Zou, Juan Juan Shen, Ying Li, Zi Ping Zhang, Yi Lei WangAbstractAs a member of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family, TRAF3 is an important regulator of NF-κB and type I interferon (IFN) activation, especially in Toll-like receptors (TLRs)- and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs)-mediated signaling pathway. In the present study, a TRAF3 homologue named Lc-TRAF3 was characterized in large yellow croaker (Larimichthys crocea). The open reading frame (ORF) ...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 10 December 2019Source: Comparative Biochemistry and Physiology Part A: Molecular &Integrative PhysiologyAuthor(s): Jorge Félix Beltrán Lissabet, Lisandra Herrera, Manuel Lee-Estevez, Jennie Risopatrón, Iván Valdebenito, Elías Figueroa, Jorge G. FaríasAbstractAmong all the Ca2+ channels, CatSper channels have been one of the most studied in sperm of different species due to their demonstrated role in the fertilization process. In fish sperm, the calcium channel plays a key role in sperm activation. However, the functionality of the CatSper cha...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - Category: Biochemistry Source Type: research
Authors: Segal O, Kollander Y, Gosheger G PMID: 31814350 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Conditions:   Ageing;   Mitochondrial Function;   Physical Function;   Cognitive Function Interventions:   Dietary Supplement: Fish oils and dairy fat;   Dietary Supplement: Fish oils and plant fat Sponsors:   Maastricht University;   Wageningen University and Research;   Netherlands Organisation for Scientific Research;   Top Institute Food and Nutrition Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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