Evaluating the Efficacy and Safety of Xalost S in Glaucoma Patients.

Condition:   Glaucoma Interventions:   Drug: Xalost S;   Drug: Xalatan;   Drug: Taflotan-S Sponsor:   Taejoon Pharmaceutical Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
We reported an isolated case and 1 family with several individuals affected by CS. The isolated case showed typical features including fibrocystic breast disease, benign thyroid nodules, and multiple papillomatous lesions in the face and oral cavity and was caused by a novel nonsense mutation (c.940 G>T) in the PTEN gene. In the family, the proband showed erythema nodosum, duodenal ulcer, intestinal polyps, cervical lipoma, renal cysts, and glaucoma, whereas her family revealed multiple members with intestinal polyps and a sister with breast cancer diagnosed at early age.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
CONCLUSIONS The results suggest that by regulating the expression of BMPs, ANGPTL7 directly promotes proliferation, differentiation, and mineralization of osteoblasts. PMID: 31835268 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSION: The present study provides detailed estimates for AACG incidence according to all age groups and gender through the 5-year study period. PMID: 31833263 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
We describe various retinal image datasets that can be used for deep learning purposes. Applications of deep learning for segmentation of optic disk, optic cup, blood vessels as well as detection of lesions are reviewed. Recent deep learning models for classification of diseases such as age-related macular degeneration, glaucoma, and diabetic retinopathy are also discussed. Important critical insights and future research directions are given.
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Authors: Yoon JY, Sung KR, Yun SC, Shin JW Abstract PURPOSE: To explore the progressive change and associated factors of optic disc tilt in young myopic glaucomatous eyes by analyzing long-term follow-up data. METHODS: Optic disc images were obtained from spectral-domain optical coherence tomography enhanced depth imaging from at least five different visits. At each visit, the disc tilt angle (DTA), defined as the angle between the Bruch's membrane opening plane and the optic canal plane, was estimated at the central frame that passes through the optic disc. Glaucoma progression was assessed on the basis of cha...
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
Publication date: Available online 14 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Iqbal Ahmad, Pooja Teotia, Helen Erickson, Xiaohuan XiaAbstractDegeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat blinding diseases through regenerative medicine appears a near ...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Abstract Retinal ganglion cell (RGC) death is the central and irreversible endpoint of optic neuropathies. Current management of optic neuropathies and glaucoma focuses on intraocular pressure-lowering treatment which is insufficient. As such, patients are effectively condemned to irreversible visual impairment. This review summarizes experimental treatments targeting RGCs over the last decade. In particular, we examine the various treatment modalities and determine their viability and limitations in translation to clinical practice. Experimental RGC treatment can be divided into (1) cell replacement therapy, (2) ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: High-frequency deep sclerotomy is a safe and promising minimally invasive procedure which successfully achieves a lower IOP for chronic open-angle glaucoma patients, but not adequate for advanced glaucoma patients. This trial is registered with PACTR201910823824561. PMID: 31828092 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Authors: Zhou W, Yi Y, Gao Y, Dai J Abstract Accurate optic disc and optic cup segmentation plays an important role for diagnosing glaucoma. However, most existing segmentation approaches suffer from the following limitations. On the one hand, image devices or illumination variations always lead to intensity inhomogeneity in the fundus image. On the other hand, the spatial prior knowledge of optic disc and optic cup, e.g., the optic cup is always contained inside the optic disc region, is ignored. Therefore, the effectiveness of segmentation approaches is greatly reduced. Different from most previous approaches, we...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
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