Photoreceptors from Embryonic Stem Cells

From The Guardian:Embryonic stem cells could help restore sight to blindPhotoreceptors grown from embryonic stem cells have been successfully implanted in the retinas of blind miceAlok Jha, Science CorrespondentThe Guardian Sunday 21 July 2013 18.00 BST Read the article
Source: BrainBlog - Category: Neurologists Source Type: blogs

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Conclusions: Adipose expression of TBX1 is necessary, but not sufficient, to defend body temperature during cold via proper UCP1 expression. Adipose TBX1 expression was also required for proper insulin signaling in subcutaneous adipose as well as maintaining β-adrenergic sensitivity but overexpression of TBX1 was not sufficient to induce adipocyte beiging or prevent diet induced obesity. TBX1 expression is enriched in adipose stem cells in which it has contrasting effects on adipogenesis in mouse versus human cells. Collectively, these data demonstrate the importance of adipose TBX1 in the regulation of beige adipocyt...
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
ConclusionT2B2F is associated with a higher incidence of acute GVHD compared with T1B2F. These results suggest that a lower dose-intensity of thiotepa and busulfan in the TBF regimen may yield better results in patients with AML in CR.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Conclusion Multiple myeloma patients who received HDC/ASCT demonstrated a significant decrease in 18FDG uptake in the supratentorial brain and cerebellum, while patients who received CDC did not demonstrate significant changes in the brain 18FDG uptake.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Publication date: Available online 19 February 2020Source: Stem Cell ResearchAuthor(s): Rong Li, Manisha Pradhan, Miao Xu, Amanda Baskfield, Jeanette Beers, Jizhong Zou, Chengyu Liu, Forbes D. Porter, Wei ZhengAbstractNiemann-Pick disease, type C (NPC) is a rare autosomal recessive genetic disease caused by mutations in either NPC1 or NPC2, which encodes an intracellular cholesterol-binding protein in lysosome. Deficiency of either NPC1 or NPC2 protein results in malfunction of intracellular cholesterol trafficking and lysosomal accumulation of unesterified cholesterols. A human induced pluripotent stem cell (iPSC) line wa...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 18 February 2020Source: Stem Cell ResearchAuthor(s): Alan T.L. Lam, Shaul Reuveny, Steve Kah-Weng OhAbstractArticular cartilage defects are one of the major challenges in orthopedic and trauma surgery. However, the poor ability of cartilage to self-repair has motivated efforts to engineer replacement tissues, and human mesenchymal stem cells (MSC), which have an extensive proliferation potential and can undergo chondrogenesis, have emerged as a promising cell source. In this review, we attempt to provide a brief overview of MSC isolation, characterization, current manufacturing platforms ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Leigh D. Plant, Dazhi Xiong, Jesus Romero, Hui Dai, Steve A.N. GoldsteinSummaryAcute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the action potential. NaV1.5 is SUMOylated only on lysine 442, and the mutation of that residue, or application of a deSUMOylating enzyme, prevents hypoxic reopenings. The time course of SUMOylation of sing...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Michela Bartoccetti, Bernard K. van der Veer, Xinlong Luo, Rita Khoueiry, Pinyi She, Manmohan Bajaj, Jiayi Xu, Adrian Janiszewski, Bernard Thienpont, Vincent Pasque, Kian Peng KohSummaryReprogramming somatic cells into induced pluripotent stem cells (iPSCs) involves the reactivation of endogenous pluripotency genes and global DNA demethylation, but temporal resolution of these events using existing markers is limited. Here, we generate murine transgenic lines harboring reporters for the 5-methylcytosine dioxygenase Tet1 and for Oct4. By mo...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Chao Chen, Ming-an Sun, Claude Warzecha, Mahesh Bachu, Anup Dey, Tiyun Wu, Peter D Adams, Todd Macfarlan, Paul Love, Keiko OzatoSummaryHIRA is a histone chaperone that deposits the histone variant H3.3 in transcriptionally active genes. In DiGeorge syndromes, a DNA stretch encompassing HIRA is deleted. The syndromes manifest varied abnormalities, including immunodeficiency and thrombocytopenia. HIRA is essential in mice, as total knockout (KO) results in early embryonic death. However, the role of HIRA in hematopoiesis is poorly understood...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Andrea M. Chiariello, Simona Bianco, A. Marieke Oudelaar, Andrea Esposito, Carlo Annunziatella, Luca Fiorillo, Mattia Conte, Alfonso Corrado, Antonella Prisco, Martin S.C. Larke, Jelena M. Telenius, Renato Sciarretta, Francesco Musella, Veronica J. Buckle, Douglas R. Higgs, Jim R. Hughes, Mario NicodemiSummaryWe investigate the three-dimensional (3D) conformations of the α-globin locus at the single-allele level in murine embryonic stem cells (ESCs) and erythroid cells, combining polymer physics models and high-resolution Capture-C d...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Rocco Lucero, Valentina Zappulli, Alessandro Sammarco, Oscar D. Murillo, Pike See Cheah, Srimeenakshi Srinivasan, Eric Tai, David T. Ting, Zhiyun Wei, Matthew E. Roth, Louise C. Laurent, Anna M. Krichevsky, Xandra O. Breakefield, Aleksandar MilosavljevicSummaryGlioblastoma (GBM) is characterized by aberrant vascularization and a complex tumor microenvironment. The failure of anti-angiogenic therapies suggests pathways of GBM neovascularization, possibly attributable to glioblastoma stem cells (GSCs) and their interplay with the tumor micro...
Source: Cell Reports - Category: Cytology Source Type: research
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