When Depression Hides a Brain Tumor: A Case of Glioblastoma.

When Depression Hides a Brain Tumor: A Case of Glioblastoma. Prim Care Companion CNS Disord. 2019 Nov 14;21(6): Authors: Ferreira LP, Pinheiro CF, Fernandes NA, Ferreira CN PMID: 31730304 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

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Publication date: Available online 23 November 2019Source: Journal of Clinical NeuroscienceAuthor(s): Robert G. Briggs, Syed A. Ahsan, Andrew K. Conner, Cameron E. Nix, Christina C. Jacobs, Ryan G. Jones, John R. Sheets, Ali H. Palejwala, Kassem Chendeb, Michael E. SughrueAbstractA unique challenge in some brain tumor patients is the fact that tumors arising in certain areas of the brain involve the neural structures of consciousness or alertness, limiting the patient’s ability to participate in rehabilitation following surgery. A critical question is whether neurostimulant therapy can help patients participate in re...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
This study analyzes the tumor homing and therapeutic abilities of clinical grade human mesenchymal stem cells (MSCs) in an orthotopic glioblastoma mouse model. Our time course analysis demonstrated that MSCs display a rapid targeted migration to intracerebral U87 glioma xenografts growing in the contralateral hemisphere within the first 48h hours after application as assessed by histology and 7T magnetic resonance imaging. MSCs accumulated predominantly peritumorally but also infiltrated the main tumor mass and targeted distant tumor satellites while no MSCs were found in other regions of the brain. Intratumoral applicatio...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
CONCLUSION: This research suggested that the MSCTK/GCV system exerts a strong bystander effect on GBM tumor cells, and this system may be a promising assistant method for GBM postoperative therapy. PMID: 31657679 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research
Dive into this week’s Psychology Around the Net for the latest on better understanding the nuances of today’s casual relationships, how Americans feel politics are affecting their stress levels, relationships, and sleep, tips to reduce your exaggerated emotions, and more! Stressed Out: Americans Making Themselves Sick Over Politics: Surely this comes as a surprise to no one. New research from the University of Nebraska-Lincoln reports that nearly 40% of survey participants says politics is stressing them out; 4% said they’ve had suicidal thoughts related to politics. One in five participants report losin...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net Sports Stress Athletes casual relationships Mental Habits Nba Politics WNBA Source Type: blogs
Conclusion: Quality of sleep in patients with insomnia following brain tumor resection was initially poor but improved significantly after taking hypnotic medication. Further, the hypnotic medications appeared to contribute to the amelioration of cognitive impairments and depressive moods in patients who previously underwent brain tumor resection. We thus recommend the use of hypnotics for patients with brain tumors with insomnia. PMID: 31533416 [PubMed - as supplied by publisher]
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
Publication date: Available online 3 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Li-xia Qin, Jie-qiong Tan, Hai-nan Zhang, Jian-guang Tang, Bo Jiang, Xiang-min Shen, Bei-sha Tang, Chun-yu WangAbstractmicroRNAs have been reported to suppress tumor growth, invasion, and metastasis and play roles in neurodegeneration disorders. Moreover, changes in microRNAs are found in the peripheral blood, cerebrospinal fluid (CSF), and brain tissues in patients of central nervous system diseases, including glioma, Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis and depression. Compar...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: The findings of this study has addressed the literature gap by showing pediatric brain tumors have poorer psychological well-being, in terms of greater number of depressive symptoms, lower levels of self-esteem, and more severely compromised quality of life than survivors of other pediatric cancers. It is vital for healthcare professionals to develop and evaluate appropriate interventions with the aims to enhance the psychological well-being and quality of life among pediatric brain tumor survivors. PMID: 31358242 [PubMed - in process]
Source: European Journal of Oncology Nursing - Category: Nursing Authors: Tags: Eur J Oncol Nurs Source Type: research
ConclusionsAdult brain tumour survivors were found to experience poorer SCF than healthy controls after accounting for anxiety. SCF was related to multiple factors after brain tumour; however, an independent association with anxiety was identified.Implications for Cancer SurvivorsThese findings highlight the potential value of psychological interventions targeting anxiety and cognitive effects to improve quality of survivorship after brain tumour.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
a Masashi Okada Glioblastoma is a primary brain tumor associated with a poor prognosis due to its high chemoresistance capacity. Cancer stem cells (CSCs) are one of the mechanisms of chemoresistance. Although therapy targeting CSCs is promising, strategies targeting CSCs remain unsuccessful. Abnormal activation of epidermal growth factor receptors (EGFRs) due to amplification, mutation, or both of the EGFR gene is common in glioblastomas. However, glioblastomas are resistant to EGFR tyrosine kinase inhibitors (EGFR-TKIs), and overcoming resistance is essential. Brexpiprazole is a new, safe serotonin-dopamine activity...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Li X, Chu S, Liu Y, Chen N Abstract Rhubarb is a well-known traditional Chinese medicine; it has been used in China for thousands of years. Rhubarb anthraquinones are the major medicinal ingredients derived from rhubarb including emodin, aloe-emodin, chrysophanol, rhein, physcion, and danthron. These different anthraquinone derivatives alone or in combination play a therapeutic role in central nervous system diseases (CNSD), such as cerebral ischemic stroke, intracerebral hemorrhage, traumatic brain injury, brain tumor, Alzheimer's disease, depression, and others. We review the experimental studies on thes...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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