Crocins: The Active Constituents of Crocus Sativus L. Stigmas, Exert Significant Cytotoxicity on Tumor Cells In Vitro

Conclusion: Our data demonstrate that crocins could be a novel promising agent for the improvement of tumor treatment.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research

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Background: Long-term survival after childhood cancer has improved over recent decades but survivors may face an increased lifelong risk of adverse health effects such as an impairment in lung function. Spirometry is insufficiently sensitive to detect abnormalities precociously and Lung Clearance Index (LCI) has been described to be more sensitive in the early stages of some lung diseases.Aim: To establish whether LCI might be useful in the follow-up of off-treatment childhood cancer survivors.Methods: We evaluated 47 off-treatment childhood cancer survivors (12.5 ± 2.2 years old) and 50 age-matched healthy controls...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric bronchology Source Type: research
ConclusionsThe LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.
Source: American Heart Journal - Category: Cardiology Source Type: research
This article outlines the current state of knowledge regarding cardiotoxicity in children undergoing cancer therapies, including the impact of specific oncologic therapies, recommendations for cardiovascular screening, the management of established cardiac disease, and the evolving field of pediatric cardio-oncology.
Source: Cardiology Clinics - Category: Cardiology Authors: Source Type: research
We examined the impact of 24 preclinical and trial design variables for their influence on 132 phase II pediatric oncology clinical trials. Success was determined by an objective assessment of patient response, with data analyzed using Fisher's exact test, Pearson's chi‐square test, and logistic regression models.Results.Trials that evaluated patients with a single histological cancer type were more successful than those that assessed multiple different cancer types (68% vs. 47%, 27%, and 17% for 1, 2–3, 4–7, and 8+; p 
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Neuro-Oncology, New Drug Development and Clinical Pharmacology, Clinical Trial Results Pediatric Oncology Source Type: research
Abstract Childhood cancer survivors are at risk for chronic health conditions related to their cancer or their therapy. Of these chronic sequelae, endocrinopathies are some of the most common complications and may include thyroid disorders, reproductive and pituitary dysfunction, and metabolic syndrome. It is important for the primary care physician and endocrinologist to be aware of these possible consequences, as many of them develop months or years after the initial cancer diagnosis and therapy. They may affect adolescents and young adults during a vulnerable time, when they are ideally transitioning into a mor...
Source: Pediatric Annals - Category: Pediatrics Authors: Tags: Pediatr Ann Source Type: research
Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. Therapies for paediatric ALL have improved such that more than 80% of patients survive to 5 years post-therapy, and most survive to adulthood. However, these ALL patients experience long-term side effects, which permanently affect their quality of life. Bone loss is the most common skeletal abnormality in paediatric ALL survivors, and 40% of patients experience a fracture before therapy completion. Reduced longitudinal growth (short stature) is another significant side effect of ALL therapy.
Source: Experimental Hematology - Category: Hematology Authors: Tags: 3129 Source Type: research
ConclusionThe majority of childhood cancer survivors at high risk of cardiac toxicity or SMN do not receive evidence-based surveillance. There is paucity of rigorous studies evaluating interventions to increase surveillance in this population.Implications for Cancer SurvivorsRobust trials are needed to assess whether tailored interventions, designed based on unique characteristics and needs of each survivor population, could improve adherence.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
AbstractPurposeTo estimate the population-based incidence of HPV vaccination after childhood cancer.MethodsPediatric and young adult cancer survivors identified in the institutional Comprehensive Cancer Center registry were linked to the North Carolina Immunization Registry (NCIR). Initiation and completion of any HPV vaccine was evaluated in survivors born between 1984 and 2002 with an NCIR record by December 2014. Descriptive statistics and Kaplan-Meier estimates of cumulative incidence were stratified by sex and age at eligibility for vaccine. Cox proportional hazards were conducted and stratified by sex.ResultsAmong 87...
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
Abstract Neuro-oncology is a young and emerging discipline. An interdisciplinary mindset and concerted actions in specialized expert teams are required to meet the challenges, not only in clinical patient care but also in research activities. A close communication network between clinician scientists, medical scientists and data scientists is required to ensure that emerging data from basic, translational and clinical research can be used for improving the sometimes extremely limited and prognostically unsatisfactory treatment options. The continuously developing spectrum of tasks in neuro-oncology inclu...
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research
Purpose of review This systematic review evaluates the state of the art in terms of strategies used to detect and remove contaminated malignant cells from testicular biopsy prior to spermatogonia stem cells (SSCs) autotransplantation to restore fertility. Recent findings Several trials have been done in past two decades to determine the reliable methods of detecting and purging cancer cells prior to SSCs autotransplantation. Summary The success in treating childhood cancer has dramatically increased over the past few decades. This leads to increasing demand for a method of fertility preservation for patients with p...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: ANDROGENS: Edited by David Handelsman Source Type: research
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